S3828
精脒
99%
别名:
1,8-二氨基-4-氮杂辛烷, N-(3-氨基丙基)-1,4-丁烷
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线性分子式:
NH2(CH2)3NH(CH2)4NH2
化学文摘社编号:
分子量:
145.25
EC Number:
204-689-0
UNSPSC Code:
12352103
MDL number:
Beilstein/REAXYS Number:
1698591
assay
99%
refractive index
n20/D 1.479 (lit.)
density
0.925 g/mL at 25 °C (lit.)
SMILES string
NCCCCNCCCN
InChI
1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
InChI key
ATHGHQPFGPMSJY-UHFFFAOYSA-N
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Biochem/physiol Actions
抑制神经元型一氧化氮合成酶（nNOS）。结合和沉淀DNA，可用于DNA结合蛋白纯化。激活T4聚核苷酸激酶活性。
抑制神经元型一氧化氮合成酶（nNOS）。结合和沉淀DNA；激活T4聚核苷酸激酶活性。
Disclaimer
如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
233.6 °F - closed cup
flash_point_c
112 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
新产品
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Chung Tsen et al.
Journal of medicinal chemistry, 51(2), 324-330 (2008-01-01)
Polyamine transport is elevated in many tumor types, suggesting that toxic polyamine-drug conjugates could be targeted to cancer cells via the polyamine transporter (PAT). We have previously reported the use of Chinese hamster ovary (CHO) cells and its PAT-deficient mutant
Navneet Kaur et al.
Journal of medicinal chemistry, 51(5), 1393-1401 (2008-02-20)
Several disubstituted arylene- and chloroambucil-polyamine conjugates were synthesized and evaluated for their ability to target cells via their polyamine transport system (PAT). As compared to the monosubstituted analogues, the disubstituted arylene systems were superior PAT targeting agents. Using a Chinese
Jean-Guy Delcros et al.
Journal of medicinal chemistry, 49(1), 232-245 (2006-01-06)
Five sets of heterocyclic derivatives of various sizes and complexities coupled by an amidine function to putrescine, spermidine, or spermine were prepared. They were essentially tested to determine the influence of the polyamine chain on their cellular transport. To comment
Marc-Antoine Bazin et al.
Bioorganic & medicinal chemistry, 16(14), 6860-6866 (2008-06-19)
Nine usnic acid-amine conjugates were evaluated on murine and human cancer cell lines. The polyamine derivatives showed significant cytotoxicity in L1210 cells. Their activities appeared to be independent of the polyamine transport system (PTS). Indeed, their activities were similar in
Dong-Hyeon Kwon et al.
Antimicrobial agents and chemotherapy, 51(6), 2070-2077 (2007-04-18)
Biogenic polyamines (e.g., spermidine and spermine) are a group of essential polycationic compounds found in all living cells. The effects of spermine and spermidine on antibiotic susceptibility were examined with gram-negative Escherichia coli and Salmonella enterica serovar Typhimurium bacteria and
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