T90204
L-色氨酸
99%
别名:
(S)-2-氨基-3-（3-吲哚基）丙酸, L-α-氨基-3-吲哚丙酸
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关于此项目
经验公式（希尔记法）:
C11H12N2O2
化学文摘社编号:
分子量:
204.23
EC Number:
200-795-6
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
86197
InChI
1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1
InChI key
QIVBCDIJIAJPQS-VIFPVBQESA-N
SMILES string
N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
assay
99%
optical activity
[α]20/D −31.5°, c = 1 in H2O
optical purity
ee: 99% (GLC)
mp
280-285 °C (dec.) (lit.)
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Application
用于合成桥联吲哚生物碱。
Other Notes
血清素和褪黑素的氨基酸前体
存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Journal of the Chemical Society. Chemical Communications, 1559-1559 (1994)
Claudia Temperini et al.
Bioorganic & medicinal chemistry, 16(18), 8373-8378 (2008-09-09)
An activation study of mammalian carbonic anhydrase (CA, EC 4.2.1.1) isoforms I-XIV with D- and L-tryptophan has been performed both by means of kinetic and X-ray crystallographic techniques. These compounds show a time dependent activity against isozyme CA II, with
Rafat M Mohareb et al.
Bioorganic & medicinal chemistry, 19(9), 2966-2974 (2011-04-16)
There is a great deal of interest in neurotrophin therapy to prevent neuronal degeneration. The present study aimed at synthesizing new functionalized indole derivatives with structures justifying neuroprotective activity using L-tryptophan (TRP) as starting material. The potential neuroprotective effect of
Eduard Dolusić et al.
Journal of medicinal chemistry, 54(15), 5320-5334 (2011-07-06)
Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active area of research in drug development. Recently, our group has shown that tryptophan 2,3-dioxygenase
Huixi Zou et al.
Journal of natural products, 72(1), 44-52 (2008-12-31)
This study reports that a series of tryptophan derivatives with modifications on the side chain or at the indole ring were accepted by two cyclic dipeptide prenyltransferases, CdpNPT and FtmPT1, and converted to prenylated derivatives. The structures of the enzymatic
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