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Merck
CN

W238104

氢化肉桂酸内酯

≥99%, FCC, FG

别名:

1,2-苯并二氢吡喃酮, 二氢香豆素, 苯并二氢吡喃酮

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关于此项目

经验公式(希尔记法):
C9H8O2
化学文摘社编号:
分子量:
148.16
FEMA Number:
2381
Council of Europe no.:
535
UNSPSC Code:
12164502
PubChem Substance ID:
Flavis number:
13.009
EC Number:
204-354-9
NACRES:
NA.21
MDL number:
Organoleptic:
coconut; coumarin; sweet
Grade:
FG
Halal
Kosher
Biological source:
synthetic
Agency:
meets purity specifications of JECFA
Food allergen:
no known allergens
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产品名称

氢化肉桂酸内酯, ≥99%, FCC, FG

SMILES string

O=C1CCc2ccccc2O1

InChI

1S/C9H8O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2

InChI key

VMUXSMXIQBNMGZ-UHFFFAOYSA-N

biological source

synthetic

grade

FG
Halal
Kosher

agency

meets purity specifications of JECFA

reg. compliance

EU Regulation 1334/2008 & 178/2002
FCC
FDA 21 CFR 117

assay

≥99%

refractive index

n20/D 1.556 (lit.)

bp

272 °C (lit.)

mp

24-25 °C (lit.)

density

1.169 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

coconut; coumarin; sweet

Quality Level

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Application


  • 新型辐射分解诱导的二氢香豆素作为有效的酪氨酸酶抑制剂:本研究鉴定了通过辐射分解产生的新型二氢香豆素,证明了其作为有效酪氨酸酶抑制剂的潜力,这在皮肤病学及相关领域具有重要应用前景。(Jeong 等人,2024 年)(Jeong 等人,2024 年)。

Biochem/physiol Actions

10ppm 时的味道

General description

二氢香豆素通常在食品和化妆品工业中用作调味成分。它天然存在于草木犀(甜三叶草)中。

Other Notes

天然存在:草木樨和鹿舌。

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

>212.0 °F - closed cup

flash_point_c

> 100 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Katrin Häser et al.
Journal of agricultural and food chemistry, 54(17), 6236-6240 (2006-08-17)
Natural dihydrocoumarin, which is of great interest in the flavor industry, was biotechnologically produced from pure coumarin or tonka bean meal with Pseudomonas orientalis, Bacillus cereus, and various Saccharomyces cerevisiae strains. Coumarin was shown to be converted to melilotic acid
Tomohiro Doura et al.
Chemical communications (Cambridge, England), 48(10), 1565-1567 (2011-05-18)
The first dual activatable hypochlorite ((-)OCl)-sensing probe was developed, based on a new proof-of-concept design involving signal-activatable (1)H chemical probes using the triple-resonance NMR technique. The probe enabled fluorescence-(1)H MR dual turn-on detection of (-)OCl in solution and in crude
Sharona Shachan-Tov et al.
Free radical biology & medicine, 49(10), 1516-1521 (2010-08-31)
Afri et al. reported in this journal (Free Radic. Biol. Med.32:605-618; 2002) that a direct relationship exists between the depth of alkanoylcoumarins 1 within the liposomal lipid bilayer and the rate at which they undergo superoxide-mediated saponification. These results were
F N Marzulli et al.
Contact dermatitis, 6(2), 131-133 (1980-01-01)
Further confirmation of the effects of vehicles and elicitation concentration in experimental contact sensitization testing with fragrance ingredients is reported. A dose-response relation was seen when sensitized human subjects were challenged with dihydrocoumarin, alantroot oil and diethylmalleate. Furthermore, alcohol was
Jakub Modranka et al.
Bioorganic & medicinal chemistry, 20(16), 5017-5026 (2012-07-14)
A series of new 3-methylidenechroman-2-ones bearing various aromatic moieties and various substituents at position 4 were synthesized in a three step reaction sequence. Friedel-Crafts alkylation of phenols or naphthols using ethyl 3-methoxy-2-diethoxyphosphorylacrylate in the presence of trifluoromethanesulphonic acid gave 3-diethoxyphosphorylchromen-2-ones.

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