W238104
氢化肉桂酸内酯
≥99%, FCC, FG
别名:
1,2-苯并二氢吡喃酮, 二氢香豆素, 苯并二氢吡喃酮
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关于此项目
经验公式（希尔记法）:
C9H8O2
化学文摘社编号:
分子量:
148.16
FEMA编号:
2381
EC 号:
欧洲委员会编号:
535
MDL编号:
UNSPSC代码:
12164502
PubChem化学物质编号:
Flavis编号:
13.009
NACRES:
NA.21
Agency:
meets purity specifications of JECFA
生物来源
synthetic
质量水平
等级
FG
Halal
Kosher
Agency
meets purity specifications of JECFA
管理合规性
EU Regulation 1334/2008 & 178/2002
FCC
FDA 21 CFR 117
方案
≥99%
折射率
n20/D 1.556 (lit.)
沸点
272 °C (lit.)
mp
24-25 °C (lit.)
密度
1.169 g/mL at 25 °C (lit.)
应用
flavors and fragrances
文件
see Safety & Documentation for available documents
食品过敏原
no known allergens
性状检查
coconut; coumarin; sweet
SMILES字符串
O=C1CCc2ccccc2O1
InChI
1S/C9H8O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-4H,5-6H2
InChI key
VMUXSMXIQBNMGZ-UHFFFAOYSA-N
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一般描述
二氢香豆素通常在食品和化妆品工业中用作调味成分。它天然存在于草木犀（甜三叶草）中。
应用
- 新型辐射分解诱导的二氢香豆素作为有效的酪氨酸酶抑制剂：本研究鉴定了通过辐射分解产生的新型二氢香豆素，证明了其作为有效酪氨酸酶抑制剂的潜力，这在皮肤病学及相关领域具有重要应用前景。（Jeong 等人，2024 年）（Jeong 等人，2024 年）。
生化/生理作用
10ppm 时的味道
其他说明
天然存在：草木樨和鹿舌。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Skin Sens. 1
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
>212.0 °F - closed cup
闪点(°C)
> 100 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
J P Guillot et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 21(6), 795-805 (1983-12-01)
An evaluation was made of the different protocols recommended by the Association Française de Normalisation (AFNOR) for assessing the sensitizing potential of chemicals in the guinea-pig. The methods studied were those of Magnusson & Kligman (J. invest. Derm. 1969, 52
Shiyong Peng et al.
Organic & biomolecular chemistry, 10(13), 2537-2541 (2012-03-01)
3,4-Dihydrocoumarins, considered to be valuable building blocks, have attracted considerable attention due to their various biological activities. Herein, we have documented an efficient and convenient double decarboxylation process for the synthesis of 4-substituted 3,4-dihydrocoumarin in moderate to excellent yields under
Ahmad Shaabani et al.
Organic letters, 10(12), 2581-2584 (2008-05-28)
A novel isocyanide-based four-component reaction between a 2-hydroxybenzaldehyde, Meldrum's acid, an isocyanide, and an aromatic or an aliphatic alcohol efficiently provide 3,4-dihydrocoumarin derivatives in good to excellent yields without using any catalyst or activation. The reaction can be carried out
S L Born et al.
Toxicology and applied pharmacology, 151(1), 45-56 (1998-08-26)
Coumarin is a known hepatotoxicant in laboratory animals, particularly rats. However, the mouse lung was identified as a major target organ in a chronic bioassay, with an oral gavage dosage of 200 mg/kg coumarin increasing the incidence of alveolar/bronchiolar adenomas
F N Marzulli et al.
Contact dermatitis, 6(2), 131-133 (1980-01-01)
Further confirmation of the effects of vehicles and elicitation concentration in experimental contact sensitization testing with fragrance ingredients is reported. A dose-response relation was seen when sensitized human subjects were challenged with dihydrocoumarin, alantroot oil and diethylmalleate. Furthermore, alcohol was
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