InChI
1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h15,17-18,20-25,28-30H,5-14,16H2,1-4H3/t17-,18-,20+,21-,22+,23+,24+,25+,26+,27-/m1/s1
InChI key
RXMHNAKZMGJANZ-BMOLSTJGSA-N
SMILES string
[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC[C@@H](C)CO
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700025P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
7β,27-dihydroxycholesterol is a substrate for enzyme 11β-hydroxysteroid dehydrogenases (11β-HSDs).
Application
7β,27-dihydroxycholesterol has been used as an internal standard in ultra-performance liquid chromatography -tandem mass spectrometer (UPLC-MS/MS). It has also been used as a substrate for 11β-hydroxysteroid dehydrogenases (11β-HSDs) in human embryonic kidney cells (HEK293).
Biochem/physiol Actions
7β,27-dihydroxycholesterol (7β27OHC) is a retinoid-related orphan receptor γ (RORγ) ligand. 7β27OHC favors smoothened (Smo) functionality.
Packaging
5 mL Amber Glass Screw Cap Vial (700025P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
11beta-Hydroxysteroid dehydrogenases control access of 7beta, 27-dihydroxycholesterol to retinoid-related orphan receptor gamma
Beck KR, et al.
Journal of Lipid Research, 60(9), 1535-1546 (2019)
Assessment of Altered Cholesterol Homeostasis by Xenobiotics Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
Herron J, et al.
Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (editor-in-chief) ... [Et al.], 78(1), e65-e65 (2018)
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