方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (700029P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
一般描述
3β,7β-dihydroxy-5-cholestenoic acid (3β,7β-diHCA) is associated with plasma and is a C27 acid. 3β,7β-diHCA is synthesized from 3β-hydroxy-7-oxocholest-5-en-(25R)26-oic acid (3βH,7O-CA) by the action of the enzyme hydroxysteroid 11-β dehydrogenase 1.
应用
3β,7β-dihydroxy-5-cholestenoic acid may be used as an authentic diastereoisomer standard in mass spectrometry (MS) experiments.
生化/生理作用
3β,7β-dihydroxy-5-cholestenoic acid (3β,7β-diHCA) levels are elevated in Niemann-Pick type C (NPC) disease and Niemann-Pick (NP) disease type B disorders. It elicits toxicity to oculomotor neurons.
包装
5 mL Amber Glass Screw Cap Vial (700029P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Sterolomics in biology, biochemistry, medicine
Griffiths WJ and Wang Y
TrAC, Trends in Analytical Chemistry, 115280-115280 (2018)
Charge-tagging liquid chromatography-mass spectrometry methodology targeting oxysterol diastereoisomers
Griffiths WJ, et al.
Chemistry and Physics of Lipids, 207, 69-80 (2017)
Metabolism of non-enzymatically derived oxysterols: clues from sterol metabolic disorders
Griffiths WJ, et al.
Free Radical Biology & Medicine, 144, 124-133 (2019)
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