InChI key
PSXQJZDFWDKBIP-UHFFFAOYSA-N
SMILES string
CC1(CC2)C(CCC3C1CCC4(C)C3CCC4C(CCCC(C)C(O)=O)C)=CC2=O
description
(25R)-cholest-4-en-26-oic acid, 3-oxo
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700083P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
3-oxo-4-cholestenoic acid (3OChA) is synthesized from cholesterol by the oxidation at the positions C3 and C26 in the presence of P450 cytochromes (CYP125 and CYP142). This pathway is well established in M. smegmatis. 3OChA is an intermediate in cholesterol catabolism and is more soluble compared to cholesterol.
Application
3-oxo-4-cholestenoic acid has been used as a inducer ligand for the TetR-like repressor (KstR) of M. smegmatis.
Biochem/physiol Actions
3-oxo-4-cholestenoic acid (3OChA) acts as an inducer to the TetR-like repressor (KstR) and modulates the expression kstR regulon genes.
Packaging
5 mL Amber Glass Screw Cap Vial (700083P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Esther García-Fernández et al.
The Journal of biological chemistry, 289(25), 17576-17588 (2014-05-08)
Cholesterol degradation plays a prominent role in Mycobacterium tuberculosis infection; therefore, to develop new tools to combat this disease, we need to decipher the components comprising and regulating the corresponding pathway. A TetR-like repressor (KstR) regulates the upper part of
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