assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700089P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
Atheronal molecules may be a new association, in the already complex inter-relationship, between inflammation, cholesterol oxidation, the tissue macrophage, and atherosclerosis.
Atheronal-B is generated by the intramolecular aldolization of atheronal-A and this interconversion is rapid. It is present in plasma and is well detectable. Atheronal A and B are also referred to as cholesterol 5,6-secosterols.
Biochem/physiol Actions
Atheronal-B levels are elevated in patients with cardiovascular disease like atherosclerosis. Atheronal A and B favor misfolding of α-synuclein, apolipoprotein-B100 and β-amyloid by adding an aldehyde group to the lysine side chain. In addition, atheronals also modify the cationic property of myelin basic protein (MBP) leading to structural change, which contributes directly to the pathogenesis of multiple sclerosis.
Packaging
5 mL Amber Glass Screw Cap Vial (700089P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Cindy Takeuchi et al.
Biochemistry, 45(23), 7162-7170 (2006-06-07)
The proatherogenic properties of the cholesterol 5,6-secosterols (atheronal-A and atheronal-B), recently discovered in atherosclerotic arteries, have been investigated in terms of their effects on monocyte/macrophage function. A fluorescent analogue of atheronal-B (1) (50 microM), when cultured in either aqueous buffer
Natalie K Cygan et al.
Biochemistry, 50(12), 2092-2100 (2011-02-15)
Myelin degradation in the central nervous system (CNS) is a clinical hallmark of multiple sclerosis (MS). A reduction in the net positive charge of myelin basic protein (MBP) via deimination of arginine to citrulline has been shown to correlate strongly
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