700133P
Avanti
3β,25-OH-7-oxo-5-cholestenoic acid
Avanti Research™ - A Croda Brand
别名:
3β,25-dihydroxy-7-oxo-5-cholestenoic acid
产品名称
3β,25-OH-7-oxo-5-cholestenoic acid, Avanti Research™ - A Croda Brand 700133P, powder
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (700133P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 700133P
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@H](C1)CC[C@](C1=C[C@H]2O)(C)C3C2C(CC[C@@H]4[C@H](C)CCCC(C)(O)CO)[C@]4(C)CC3
InChI key
JGEBMCVWDISKRI-MRAVHIDRSA-N
一般描述
3β,25-OH-7-oxo-5-cholestenoic acid is a cholesterol derivative and an oxysterol derived from cholesterol. The synthesis of CA occurs in mitochondria and the enzyme sterol 27-hydroxylase (CYP27A1) catalyzes the step.
生化/生理作用
Cholestenoic acid (CA) serves as a ligand to nuclear receptor and may be neurotoxic or neuroprotective based on their structural features. Defects in the enzymes catalyzing the formation of cholestenoic acids are implicated in disorders related to motor neuron degeneration.
包装
5 mL Amber Glass Screw Cap Vial (700133P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
法规信息
新产品
此项目有
Spyridon Theofilopoulos et al.
The Journal of clinical investigation, 124(11), 4829-4842 (2014-10-02)
Cholestenoic acids are formed as intermediates in metabolism of cholesterol to bile acids, and the biosynthetic enzymes that generate cholestenoic acids are expressed in the mammalian CNS. Here, we evaluated the cholestenoic acid profile of mammalian cerebrospinal fluid (CSF) and
Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome.
Jennifer H Madenspacher et al.
The Journal of allergy and clinical immunology, 143(1), 440-442 (2018-10-09)
Peter J Crick et al.
The Journal of steroid biochemistry and molecular biology, 195, 105475-105475 (2019-09-22)
While the presence and abundance of the major oxysterols and cholestenoic acids in the circulation is well established, minor cholesterol metabolites may also have biological importance and be of value to investigate. In this study by observing the metabolism of
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