产品名称
Bicelle Blend (DMPC:DHPC (2.8:1, mol:mol)), Avanti Research™ - A Croda Brand, powder
assay
99% (TLC)
form
powder
packaging
pkg of 2 × 100 mg (790590P-200MG)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
Bicelle blend contains 200mg of dimyristoylphosphatidylcholine (DMPC): dihexanoylphosphatidylcholine (DHPC) Pre-Mixed Bicelle (2.8:1, mol:mol). Bicelle is a discoidal lipid aggregate. It is made up of long-chain phospholipid and a detergent. The planar bilayer is generally composed of DMPC, which may have phospholipids with identical chain lengths but differ in the head group. The detergent layer is composed of a short-chain phospholipid like DHPC.
The bicelle blend is designed to aid with the production of high-quality membrane protein crystals. Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol: https://avantilipids.com/tech-support/liposome-preparation/bicelle-preparation/
Biochem/physiol Actions
Bicelles are used as membrane mimetics for studying membrane-associated biomolecules.
Packaging
5ML Amber Glass Screw Cap Vial (790590P-200MG)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
K J Glover et al.
Biophysical journal, 81(4), 2163-2171 (2001-09-22)
Several complementary physical techniques have been used to characterize the aggregate structures formed in solutions containing dimyristoylphosphatidylcholine (DMPC)/dihexanoylphosphatidylcholine (DHPC) at ratios of < or =0.5 and to establish their morphology and lipid organization as that of bicelles. (31)P NMR studies
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