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关于此项目
经验公式（希尔记法）:
C41H72 D9N2O6P
化学文摘社编号:
分子量:
738.12
MDL number:
NACRES:
NA.25
UNSPSC Code:
41141825
产品名称
18:1-d9 SM, Avanti Research™ - A Croda Brand
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (791649C-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
1 mg/mL (791649C-1mg)
shipped in
dry ice
storage temp.
−20°C
Application
18:1-d9 SM (N-oleoyl(d9)-D-erythro-sphingosylphosphorylcholine) has been used as an extraction buffer component for lipid isolation from raft and non-raft fractions of synaptic vesicles (SV) from rat brain. It may be used as an internal standard to spike serum lipid extracts for liquid chromatography-mass spectrometry (LC/MS) analysis and ultra-high-performance supercritical fluid chromatography with quadrupole-time-of-flight mass spectrometry (UHPSFC/QTOF-MS) for signal normalization and quantification of pulmonary artery lipids form porcine.
General description
18:1-d9 SM (N-oleoyl(d9)-D-erythro-sphingosylphosphorylcholine) is a deuterated derivative of 18:1-SM (N-oleoyl-D-erythro-sphingosylphosphorylcholine). 18:1- SM is a sphingomyelin which is present in aqueous humor. 18:1-SM or oleoyl-sphingomyelin, comprises quaternary ammonium group. 18:1-SM or oleoyl-sphingomyelin due to its miscible property is incapable of sequestering with cholesterol-rich domains.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH™ LIPIDOMIX™ Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample.
Packaging
5 mL Clear Glass Sealed Ampule (791649C-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
LIPIDOMIX is a trademark of Avanti Polar Lipids, LLC
SPLASH is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
易制毒化学品（2类）
危险化学品
此项目有
Richard M Epand et al.
Chemistry and physics of lipids, 132(1), 37-46 (2004-11-09)
Sphingomyelin from biological membranes forms segregated domains with cholesterol in fluid bilayers. However, a synthetic form of sphingomyelin with an oleoyl chain linked to sphingosine is not incorporated into cholesterol-rich domains. We have studied the properties of mixtures of oleoyl-sphingomyelin
Ayman J Aljohani et al.
Molecular vision, 19, 1966-1984 (2013-09-27)
To determine the differential profiles of sphingomyelin, sphingoid base, sphingoid base-1-phosphate and ceramide lipid species and their quantitative differences between control and glaucomatous aqueous humor (AQH) derived from human donors. AQH from control and primary open-angle glaucoma donors was collected
Alicia Gil-Ramirez et al.
Journal of chromatography. A, 1592, 173-182 (2019-02-03)
Pulmonary artery grafts are needed as cardiovascular bioprosthetics. For successful tissue recellularization after transplantation, lipids have to be removed from the donor artery. Developing a selective process to remove lipids without damaging the extracellular matrix greatly depends on knowing the
John Williams et al.
Bioanalysis, 12(3), 143-158 (2020-02-14)
Aim: Very long chain fatty acids (VLCFAs) have been identified as biomarkers for several peroxisomal disorders necessitating the need for reliable biomarker assays in particular C20, C22, C24, C26 in cerebrospinal fluid (CSF). Until now no absolute quantitation assay for
Michael S Gardner et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1118-1119, 137-147 (2019-04-30)
Progress toward better diagnosis and treatment of lipid metabolism-related diseases requires high throughput approaches for multiplexed quantitative analysis of structurally diverse lipids, including phospholipids (PLs). This work demonstrates a simplified "one-pot" phospholipid extraction protocol, as an alternative to conventional liquid-liquid
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