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关于此项目
经验公式（希尔记法）:
C25H48N3O7P
化学文摘社编号:
分子量:
533.64
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
N-P Tyrosine PA, Avanti Research™ - A Croda Brand 800725P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (800725P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 800725P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
General description
Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid are competitive inhibitors of the LPA receptor in Xenopus oocytes. However, in mammalian cells, N-palmitoyl-tyrosine phosphoric acid may act as an agonist for the LPA receptor. LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors. LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation.
Packaging
5 mL Amber Glass Screw Cap Vial (800725P-1mg)
Preparation Note
Product use: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid can be used for cell studies. dissolved these lipids in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells. In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection.
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Hydrolysis of phosphatidylserine-exposing red blood cells by secretory phospholipase A2 generates lysophosphatidic acid and results in vascular dysfunction.
Neidlinger, N.A, et. al.
The Journal of Biological Chemistry, 281, 775-781 (2006)
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids
Bittman, R, et. al.
Journal of Lipid Research, 37, 391-398 (1996)
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization
An, S
Molecular Pharmacology, 54, 881-888 (1998)
Nikole A Neidlinger et al.
The Journal of biological chemistry, 281(2), 775-781 (2005-11-10)
Secretory phospholipase A(2) (sPLA(2)) type IIa, elevated in inflammation, breaks down membrane phospholipids and generates arachidonic acid. We hypothesized that sPLA(2) will hydrolyze red blood cells that expose phosphatidylserine (PS) and generate lysophosphatidic acid (LPA) from phosphatidic acid that is
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids
Bittman, R
Journal of Lipid Research, 37, 391-398 (1996)
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