810107E
Avanti
NBD AEA
Avanti Research™ - A Croda Brand
别名:
20-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino] arachidonoyl ethanolamide
产品名称
NBD AEA, Avanti Research™ - A Croda Brand 810107E, ethanol solution
方案
>95% (TLC)
表单
ethanol solution
包装
pkg of 1 × 1 mL (810107E-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 810107E
浓度
1 mg/mL (810107E-1mg)
运输
dry ice
储存温度
−70°C
一般描述
The endocannabinoid pathway influences behavior, lipogenesis, embryologic development, and pathophysiological effects including pain, inflammation, stress, obesity, and non-alcoholic fatty liver disease. Endogenous endocannabinoids including arachidonoylethanolamide (anandamide, AEA) and 2-arachidonoylglycerol (2-AG) are derived from arachidonic acid (AA). Fluorescent NBD-AA and NBD-AEA analogs are direct probes that can be used for visualizing the uptake, intracellular trafficking, and targeting of these molecules by living cells, as well as measuring the binding of endocannabinoids to cytosolic binding proteins. Importantly, direct binding studies show the affinities of the fluorescent analogs are in the same range as the respective unlabeled ligands. Fluorescent endocannabinoid probes are useful for mapping the impact of various treatments, inhibitors, etc on endocannabinoid uptake and distribution in living cells.
应用
NBD AEA or 20-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino] arachidonoyl ethanolamide might be used:
- to covalently label nanoparticles for fluorescence imaging experiments
- to develop probes for the determination of direct binding affinities for wild-type (WT) human fatty acid binding protein 1 (FABP1 T94T) or FABP1 T94A analogous to that for NBD-stearic acid binding to WT rat FABP1.4
- in fluorescent ligand displacement assays to confirm the binding of phytocannabinoids and synthetic cannabinoids to FABP1
包装
5 mL Amber Glass Screw Cap Vial with Foil Bag Argon overseal (810107E-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
55.4 °F - closed cup
闪点(°C)
13.0 °C - closed cup
法规信息
新产品
此项目有
Friedhelm Schroeder et al.
Lipids, 51(6), 655-676 (2016-04-28)
The first discovered member of the mammalian FABP family, liver fatty acid binding protein (FABP1, L-FABP), occurs at high cytosolic concentration in liver, intestine, and in the case of humans also in kidney. While the rat FABP1 is well studied
Gregory G Martin et al.
Biochemistry, 56(38), 5147-5159 (2017-08-31)
Using recombinant human wild-type fatty acid binding protein 1 (WT FABP1 T94T) and a variant (FABP1 T94A) protein, fluorescence binding assays, and circular dichroism, it was shown for the first time that WT FABP1 and the T94A variant each have
Christian Kleusch et al.
Molecules (Basel, Switzerland), 17(1), 1055-1073 (2012-01-24)
In this paper a rapid and highly efficient method for controlled incorporation of fluorescent lipids into living mammalian cells is introduced. Here, the fluorescent molecules have two consecutive functions: First, they trigger rapid membrane fusion between cellular plasma membranes and
Andrew Draganski et al.
The journal of sexual medicine, 15(5), 645-653 (2018-04-28)
Curcumin, a naturally occurring anti-inflammatory compound, has shown promise in pre-clinical studies to treat erectile dysfunction (ED) associated with type-1 diabetes. However, poor bioavailability following oral administration limits its efficacy. The present study evaluated the potential of topical application of
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