810154C
Avanti
16:0-12:0 NBD PE
Avanti Research™ - A Croda Brand
别名:
1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphoethanolamine
产品名称
16:0-12:0 NBD PE, Avanti Research™ - A Croda Brand 810154C
方案
>99% (TLC)
表单
liquid
包装
pkg of 1 × 1 mL (810154C-1mg)
pkg of 5 × 1 mL (810154C-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 810154C
浓度
1 mg/mL (810154C-1mg)
1 mg/mL (810154C-5mg)
运输
dry ice
储存温度
−20°C
一般描述
N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) phosphoethanolamine (NBD PE) is a fluorescently labeled lipid with NBD attached to the headgroup of phosphatidylethanolamine (PE). It localized at the membrane interface. PE is the second most abundant, metabolically related aminophospholipid. It acts as a parent compound for phosphatidylcholine and phosphatidylethanolamine synthesis.
应用
16:0-12:0 NBD PE may be used to demonstrate the separation of fluorophore-labeled phospholipids using microfluidic chip-based technology and in liposomes preparation required to measure the phosphatidylserine decarboxylase 1 (Psd1p) activity.
生化/生理作用
Phosphoethanolamine (PE) of cardiac myocytes is useful in the prevention cell damage after ischemia. It acts as a phospholipid substrate for hepatic enzyme contributes to the one third of the phosphatidylcholine content in the liver. It is known to show extensive antitumor action and prevents tumor proliferation, in vivo.
包装
5 mL Amber Glass Screw Cap Vial (810154C-1mg)
5 mL Amber Glass Screw Cap Vial (810154C-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
危险化学品
易制毒化学品（2类）
此项目有
Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity
Lorenzo VP, et al.
Journal of Chemistry, 2016 (2016)
Application of NBD-labeled lipids in membrane and cell biology
Fluorescent methods to study biological membranes, 37-50 (2012)
Sansan Lin et al.
Analytical biochemistry, 314(1), 97-107 (2003-03-14)
Phospholipid molecules such as ceramide and phosphoinositides play crucial roles in signal transduction pathways. Lipid-modifying enzymes including sphingomyelinase and phosphoinositide kinases regulate the generation and degradation of these lipid-signaling molecules and are important therapeutic targets in drug discovery. We now
Ouma Onguka et al.
The Journal of biological chemistry, 290(20), 12744-12752 (2015-04-02)
Phosphatidylethanolamine (PE) is a major cellular phospholipid that can be made by four separate pathways, one of which resides in the mitochondrion. The mitochondrial enzyme that generates PE is phosphatidylserine decarboxylase 1 (Psd1p). The pool of PE produced by Psd1p
Jean E Vance et al.
Biochimica et biophysica acta, 1831(3), 543-554 (2012-09-11)
Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are metabolically related membrane aminophospholipids. In mammalian cells, PS is required for targeting and function of several intracellular signaling proteins. Moreover, PS is asymmetrically distributed in the plasma membrane. Although PS is highly enriched in
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