810175C
Avanti
18:1-06:0 NBD PA
Avanti Research™ - A Croda Brand
别名:
1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphate (ammonium salt)
产品名称
18:1-06:0 NBD PA, Avanti Research™ - A Croda Brand 810175C
方案
>99% (TLC)
表单
liquid
包装
pkg of 1 × 1 mL (810175C-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 810175C
浓度
1 mg/mL (810175C-1mg)
运输
dry ice
储存温度
−20°C
一般描述
Phosphatidic acid (PA) is an amphipathic lipid containing a polar head group and two long hydrophobic acyl chains. PA is an anionic and a membrane structural lipid. 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) PA is a fluorescent analog NBD attached to the sn-2 fatty acid of PA.
应用
18:1-06:0 NBD PA or 1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphate (ammonium salt) is suitable to study the effects of NBD-PA induced vesiculation on epidermal growth factor receptor (EGFR) endocytosis in mammalian cells and the co-localization of fluorescently-labeled Poly(A)-Specific Ribonuclease (PARN) with the NBD-tagged PA that outlines the close proximity phospholipase D (PLD2) and PARN.
生化/生理作用
Phosphatidic acid (PA) is a secondary messenger involved in various cellular processes and a bioactive lipid. It acts as a parent compound for more complex membrane phospholipids.
包装
5 mL Amber Glass Screw Cap Vial (810175C-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
新产品
此项目有
Bioactive Lipids
An Introduction to Biological Membranes, ,
number=(,
pages=), 453-478 (2016)
Lipid second messengers and Receptors
Encyclopedia of Endocrine Diseases, 77(3), 329-334 (2004)
Taylor E Miller et al.
Biology open, 6(2), 176-186 (2016-12-25)
The removal of mRNA transcript poly(A) tails by 3'→5' exonucleases is the rate-limiting step in mRNA decay in eukaryotes. Known cellular deadenylases are the CCR4-NOT and PAN complexes, and poly(A)-specific ribonuclease (PARN). The physiological roles and regulation for PARN is
Priya Putta et al.
Biochimica et biophysica acta, 1858(11), 2709-2716 (2016-08-03)
Phosphatidic acid (PA) is a crucial membrane phospholipid involved in de novo lipid synthesis and numerous intracellular signaling cascades. The signaling function of PA is mediated by peripheral membrane proteins that specifically recognize PA. While numerous PA-binding proteins are known
Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties
Putta P, et al.
Biochimica et Biophysica Acta, 1858(11), 2709-2716 (2016)
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