产品名称
C12-NBD Phytosphingosine, Avanti Research™ - A Croda Brand 810215C
InChI
1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1
InChI key
AERBNCYCJBRYDG-KSZLIROESA-N
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810215C-50ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810215C
concentration
0.05 mg/mL (810215C-50ug)
shipped in
dry ice
storage temp.
−20°C
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General description
C12-NBD Phytosphingosine is a fluorescent analog of biologically active sphingoid base lipid molecule, phytosphingosine. Phytosphingosine is predominantly found in the lipid lamellae. Phytosphingosine (PHS), a long-chain base sphingoid is a vital component of phytoceramides and is generally present in kidney, skin, and intestine.
Biochem/physiol Actions
Phytosphingosine (PHS) is metabolised into glycerophospholipids and other long-chain bases, including malonyl-ACP in yeast and mammalian cells. PHS is known to display skin moisturizing effect by controlling filaggrin metabolic pathways and plays an important role in coordinated formation of natural moisturizing factors and corneocyte envelope.
Packaging
5 mL Amber Glass Screw Cap Vial (810215C-50ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
新产品
此项目有
Fluorescent and Luminescent Probes for Biological Activity (1999)
Hyun Kyung Choi et al.
Archives of dermatological research, 309(10), 795-803 (2017-09-25)
Phytosphingosine (PHS) is a sphingoid that is a key component of phytoceramides NP, AP and EOP. PHS has been known to have anti-inflammation and antimicrobial activities and to stimulate epidermal differentiation. In addition, it is reported that PHS treatment notably
Li-Yu Chen et al.
Nature communications, 6, 6030-6030 (2015-01-17)
Turgor pressure plays pivotal roles in the growth and movement of walled cells that make up plants and fungi. However, the molecular mechanisms regulating turgor pressure and the coordination between turgor pressure and cell wall remodelling for cell growth remain
Natsuki Kondo et al.
Nature communications, 5, 5338-5338 (2014-10-28)
The long-chain base phytosphingosine is a component of sphingolipids and exists in yeast, plants and some mammalian tissues. Phytosphingosine is unique in that it possesses an additional hydroxyl group compared with other long-chain bases. However, its metabolism is unknown. Here
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