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Merck
CN

810227P

Avanti

C12-NBD Lactosyl Ceramide

Avanti Research - A Croda Brand

别名:

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-lactosyl-β1-1′-sphingosine

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关于此项目

经验公式(希尔记法):
C48H81N5O16
化学文摘社编号:
分子量:
984.18
MDL编号:
UNSPSC代码:
12352211
NACRES:
NA.25
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产品名称

C12-NBD Lactosyl Ceramide, Avanti Research - A Croda Brand 810227P, powder

方案

>99% (TLC)

表单

powder

包装

pkg of 1 × 50 μg (810227P-50ug)

制造商/商品名称

Avanti Research - A Croda Brand 810227P

运输

dry ice

储存温度

−20°C

一般描述

C12-NBD Lactosyl ceramide is a fluorescent analog of biologically available compound lactosyl ceramide. Lactosyl ceramideis generally present on neutrophils and macrophages.

生化/生理作用

Lactosyl ceramide is the major precursor for synthesis of various glycosphingolipids like oligoglycosylceramides and gangliosides. It is an important signaling molecule that is involved in adhesion, migration, cell proliferation and angiogenesis. Lactosyl ceramide is vital for osteoclastogenesis mediated by macrophage-colony stimulating factor.

包装

5 mL Amber Glass Screw Cap Vial (810227P-50ug)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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T Iwamoto et al.
The Journal of biological chemistry, 276(49), 46031-46038 (2001-10-11)
Glycosphingolipids and their metabolites play important roles in a variety of biological processes. Several signal molecules are localized in a glycolipid-enriched microdomain on the cell surface, and their signals are regulated by the glycolipid composition. However, the function of glycolipids
S Hakomori et al.
Journal of biochemistry, 118(6), 1091-1103 (1995-12-01)
Glycosphingolipids (GSLs), cell type-specific markers which change dramatically during ontogenesis and oncogenesis, have been implicated as playing major roles in cellular interactions and control of cell proliferation in multicellular organisms. These functional roles have been partially clarified through two types
W I Weis et al.
Annual review of biochemistry, 65, 441-473 (1996-01-01)
Lectins are responsible for cell surface sugar recognition in bacteria, animals, and plants. Examples include bacterial toxins; animal receptors that mediate cell-cell interactions, uptake of glycoconjugates, and pathogen neutralization; and plant toxins and mitogens. The structural basis for selective sugar
J W Kok et al.
The Biochemical journal, 309 ( Pt 3), 905-912 (1995-08-01)
The involvement of the plasma membrane in the metabolism of the sphingolipids sphingomyelin (SM) and glucosylceramide (GlcCer) was studied, employing fluorescent short-chain analogues of these lipids, 6-[N-(7-nitro-2,1,3-benzoxadiazol-4-yl) amino]hexanoylsphingosylphosphorylcholine (C6-NBD-SM), C6-NBD-GlcCer and their common biosynthetic precursor C6-NBD-ceramide (C6-NBD-Cer). Although these fluorescent
Subroto Chatterjee et al.
Biochimica et biophysica acta, 1780(3), 370-382 (2007-12-14)
Although lactosylceramide (LacCer) plays a pivotal role in the biosynthesis of nearly all the major glycosphingolipids, its function in regulating cellular function has begun to emerge only recently. Our current opinion is that several physiologically critical molecules such as modified/oxidized

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