810233C
Avanti
C12-NBD L-threo-Sphingosine
Avanti Research™ - A Croda Brand
别名:
N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-L-threo-sphingosine
产品名称
C12-NBD L-threo-Sphingosine, Avanti Research™ - A Croda Brand 810233C
方案
>99% (TLC)
表单
liquid
包装
pkg of 1 × 1 mL (810233C-50ug)
制造商/商品名称
Avanti Research™ - A Croda Brand 810233C
浓度
0.05 mg/mL (810233C-50ug)
运输
dry ice
储存温度
−20°C
一般描述
C12-NBD L-threo-Sphingosine is an analog of L-threo-sphingosine with a fluorescent NBD group. Sphingosine is an amino alcohol that belongs to the class of sphingolipids. L-threo-Sphingosine is one of the four isomers of sphingosine, which can be differentiated by CD spectroscopy.
生化/生理作用
Sphingosine is uniquely produced by de-acylation of ceramide. It can be converted back to ceramide by the scavenger pathway. Several studies suggest that sphingosine functions as a tumor-suppressor lipid that mediates growth arrest, senescence, apoptosis and differentiation. Treatment of cells with sphingosine is known to inhibit the activity of the mitogen activated protein kinases (MAPKs), extracellular signal-regulated kinases (Erk-1 and Erk-2), and activate stress-activated protein kinases (SAPKs) such as Jun amino-terminal kinases (JNK) and p38.
包装
5 mL Amber Glass Screw Cap Vial (810233C-50ug)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
新产品
此项目有
Sodium, 58(8), 462-466 (2016)
Joanna Woodcock
IUBMB life, 58(8), 462-466 (2006-08-19)
The sphingomyelin pathway is activated in response to many apoptotic stimuli leading to the accumulation of breakdown products ceramide and sphingosine. Ceramide has received much attention as an apoptotic second messenger whereas sphingosine has largely been overlooked as a mediator
Padmavathi Bandhuvula et al.
Journal of lipid research, 48(12), 2769-2778 (2007-09-18)
Sphingosine-1-phosphate (S1P) lyase (SPL) catalyzes the conversion of S1P to ethanolamine phosphate and hexadecenal. This enzyme plays diverse roles in physiology and disease and, thus, may be useful as a disease marker and/or drug target. Unfortunately, the radioisotope-based assay currently
Raghavendra Pralhada Rao et al.
Journal of lipids, 2013, 178910-178910 (2013-08-29)
Sphingolipids, a family of membrane lipids, are bioactive molecules that participate in diverse functions controlling fundamental cellular processes such as cell division, differentiation, and cell death. Given that most of these cellular processes form the basis for several pathologies, it
Medical Applications of Mass Spectrometry (2008)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持