产品名称
C11 TopFluor™ Dihydroceramide, N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphinganine, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 250 μg (810263P-250ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810263P
shipped in
dry ice
storage temp.
−20°C
General description
There are two types of dihydroceramide desaturases, such as DES1 and DES2. DES1 is ubiquitously present and DES2 is present in the gut and skin.
Biochem/physiol Actions
Dihydroceramide (DH-Cer) plays a key role in de novo biosynthesis of sphingolipid by acting as an intermediate. Dihydroceramide modulates autophagy. This metabolite can stimulate fibrosis in hepatic steatosis model. It can enhance the lipid droplets by damaging the autophagic flux.
Packaging
5 mL Amber Glass Screw Cap Vial (810263P-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
Dihydroceramide Biology STRUCTURE-SPECIFIC METABOLISM AND INTRACELLULAR LOCALIZATION
Kok JW, et al.
The Journal of Biological Chemistry, 272(34), 21128-21136 (1997)
Dihydroceramides: from bit players to lead actors
Siddique M M, et al.
Test, 290(25), 15371-15379 (2015)
Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model
Lee Ah young, et al.
Biochemical and biophysical research communications, 494(3-4), 460-469 (2017)
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