产品名称
Lyso PAF (from Heart PC), Avanti Research™ - A Croda Brand 840008C
InChI
1S/C24H52NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-29-22-24(26)23-31-32(27,28)30-21-19-25(2,3)4/h24,26H,5-23H2,1-4H3/t24-/m1/s1
InChI key
VLBPIWYTPAXCFJ-XMMPIXPASA-N
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (840008C-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 840008C
concentration
5 mg/mL (840008C-5mg)
lipid type
phospholipids
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
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General description
Lyso-platelet activating factor (lyso-PAF) is the alkyl homolog of lysophosphatidylcholine.
Application
Lyso PAF (from Heart PC) is suitable for use as acyl acceptors in the determination of lysophosphatidic acid acyltransferase (LPAAT) activity. It is also suitable for use in mass spectroscopic comparison for identifying the presence of tiny amounts of alkylacylphosphatidylcholine (OxPAF) in oxidized low density lipoprotein (OxLDL).
Biochem/physiol Actions
Lyso-platelet activating factor (lyso-PAF) can stimulate inflammation in a murine model of pleurisy. It acts as a stable metabolite and a precursor of PAF. The turnover of lyso-PAF to PAF is expected to induce continued inflammation in target organs or tissues.
Packaging
5 mL Clear Glass Sealed Ampule (840008C-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
flash_point_c
does not flash
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
法规信息
新产品
此项目有
Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids
Marathe GK, et al.
Journal of Lipid Research, 42(9), 1430-1437 (2001)
Study on the metabolism of lyso-platelet activating factor (lyso-PAF) in human paranasal sinus mucosa. The cultured ciliated epithelium can convert lyso-PAF to PAF
Inoue H, et al.
Life Sciences, 52(21), PL227-PL232 (1993)
Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids
Chen X, et al.
Journal of Lipid Research, 49(4), 832-846 (2008)
C Eberhardt et al.
The Journal of biological chemistry, 272(32), 20299-20305 (1997-08-08)
Lysophosphatidic acid (1-acyl-sn-glycero-3-phosphate (LPA)) is a phospholipid with diverse biological activities. The mediator serves as an intermediate in membrane phospholipid metabolism but is also produced in acute settings by activated platelets. LPA is converted to phosphatidic acid, itself a lipid
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