产品名称
Lyso PAF (from Heart PC), Avanti Research™ - A Croda Brand 840008C
方案
>99% (TLC)
表单
liquid
包装
pkg of 1 × 1 mL (840008C-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 840008C
浓度
5 mg/mL (840008C-5mg)
脂质类型
phospholipids
phosphoglycerides
运输
dry ice
储存温度
−20°C
InChI
1S/C24H52NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-29-22-24(26)23-31-32(27,28)30-21-19-25(2,3)4/h24,26H,5-23H2,1-4H3/t24-/m1/s1
InChI key
VLBPIWYTPAXCFJ-XMMPIXPASA-N
一般描述
Lyso-platelet activating factor (lyso-PAF) is the alkyl homolog of lysophosphatidylcholine.
应用
Lyso PAF (from Heart PC) is suitable for use as acyl acceptors in the determination of lysophosphatidic acid acyltransferase (LPAAT) activity. It is also suitable for use in mass spectroscopic comparison for identifying the presence of tiny amounts of alkylacylphosphatidylcholine (OxPAF) in oxidized low density lipoprotein (OxLDL).
生化/生理作用
Lyso-platelet activating factor (lyso-PAF) can stimulate inflammation in a murine model of pleurisy. It acts as a stable metabolite and a precursor of PAF. The turnover of lyso-PAF to PAF is expected to induce continued inflammation in target organs or tissues.
包装
5 mL Clear Glass Sealed Ampule (840008C-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
新产品
此项目有
Study on the metabolism of lyso-platelet activating factor (lyso-PAF) in human paranasal sinus mucosa. The cultured ciliated epithelium can convert lyso-PAF to PAF
Inoue H, et al.
Life Sciences, 52(21), PL227-PL232 (1993)
Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids
Marathe GK, et al.
Journal of Lipid Research, 42(9), 1430-1437 (2001)
Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids
Chen X, et al.
Journal of Lipid Research, 49(4), 832-846 (2008)
C Eberhardt et al.
The Journal of biological chemistry, 272(32), 20299-20305 (1997-08-08)
Lysophosphatidic acid (1-acyl-sn-glycero-3-phosphate (LPA)) is a phospholipid with diverse biological activities. The mediator serves as an intermediate in membrane phospholipid metabolism but is also produced in acute settings by activated platelets. LPA is converted to phosphatidic acid, itself a lipid
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