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Merck
CN

840065C

Avanti

18:0-22:6 PS

Avanti Research™ - A Croda Brand

别名:

1-十八烷酰基-2-(4Z,7Z,10Z,13Z,16Z,19Z-二十二碳六烯酰基)-sn-甘油-3-磷酸-L-丝氨酸(钠盐)； PS(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); 110675

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关于此项目

经验公式（希尔记法）:
C46H77NO10PNa
化学文摘社编号:
474943-18-5
分子量:
858.07
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

18:0-22:6 PS, 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phospho-L-serine (sodium salt), chloroform

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C46H78NO10P.Na/c1-3-5-7-9-11-13-15-17-19-20-21-22-24-26-28-30-32-34-36-38-45(49)57-42(40-55-58(52,53)56-41-43(47)46(50)51)39-54-44(48)37-35-33-31-29-27-25-23-18-16-14-12-10-8-6-4-2;/h5,7,11,13,17,19,21-22,26,28,32,34,42-43H,3-4,6,8-10,12,14-16,18,20,23-25,27,29-31,33,35-41,47H2,1-2H3,(H,50,51)(H,52,53);/q;+1/p-1/b7-5-,13-11-,19-17-,22-21-,28-26-,34-32-;/t42-,43+;/m1./s1

InChI key

LANGJWMFDASXLA-OMTXNCIISA-M

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840065C-25mg)
pkg of 1 × 4 mL (840065C-100mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840065C

concentration

10 mg/mL (840065C-25mg)
25 mg/mL (840065C-100mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

相关类别

Application

18:0-22:6 PS 或 1-硬脂酰-2-二十二碳六烯酰-sn-甘油-3-磷酸-L-丝氨酸（钠盐）已用于脂质体制备，以研究磷脂的脂肪酸 (FA) 谱对 dynamin 和 endophilin 的膜囊泡形成的影响

General description

在人类中，磷酸丝氨酸（PS） 存在于内质网、高尔基体和灰质中。它定位于细胞内膜、核膜、线粒体外膜、质膜和髓磷脂。

Packaging

5 mL透明玻璃密封安瓿（840065C-100mg）
5 mL透明玻璃密封安瓿（840065C-25mg）

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

wgk

WGK 3

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

易制毒化学品（2类）
危险化学品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Hee-Yong Kim et al.
Progress in lipid research, 56, 1-18 (2014-07-06)
Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the inner leaflet of the plasma membrane in neural tissues. PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is
Marco M Manni et al.
eLife, 7 (2018-03-16)
Phospholipid membranes form cellular barriers but need to be flexible enough to divide by fission. Phospholipids generally contain a saturated fatty acid (FA) at position sn1 whereas the sn2-FA is saturated, monounsaturated or polyunsaturated. Our understanding of the impact of
Peter A Leventis et al.
Annual review of biophysics, 39, 407-427 (2010-03-03)
Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma-carboxyglutamic domains and contributes to the electrostatic association of polycationic ligands with cellular membranes. Rather than being evenly

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