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Merck
CN

840506C

Avanti

18:0-22:6 PG

Avanti Research™ - A Croda Brand

别名:

1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-(1′racglycerol) (sodium salt); PG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); 110655

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关于此项目

经验公式（希尔记法）:
C46H78O10PNa
化学文摘社编号:
474943-27-6
分子量:
845.07
MDL number:
MFCD22495248
UNSPSC Code:
51191904
NACRES:
NA.25

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产品名称

18:0-22:6 PG, 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt), chloroform

SMILES string

[Na+].[P](=O)([O-])(OC[C@H](OC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)COC(=O)CCCCCCCCCCCCCCCCC)OCC(O)CO

InChI

1S/C46H79O10P.Na/c1-3-5-7-9-11-13-15-17-19-20-21-22-24-26-28-30-32-34-36-38-46(50)56-44(42-55-57(51,52)54-40-43(48)39-47)41-53-45(49)37-35-33-31-29-27-25-23-18-16-14-12-10-8-6-4-2;/h5,7,11,13,17,19,21-22,26,28,32,34,43-44,47-48H,3-4,6,8-10,12,14-16,18,20,23-25,27,29-31,33,35-42H2,1-2H3,(H,51,52);/q;+1/p-1/b7-5-,13-11-,19-17-,22-21-,28-26-,34-32-;/t43?,44-;/m1./s1

InChI key

MZXILCJOOQSOIZ-DTRIVZRESA-M

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840506C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840506C

concentration

10 mg/mL (840506C-25mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

Application

18:0-22:6 PG or 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt) has been used as a standard in bilayer vesicles for the systematic analysis of different oxidized phospholipid (Ox-PL) patterns by oxidation of PL vesicles using a Cu2+ solution. It has also been used in liposomes, to serve as an acidic phospholipid control and to determine the lipid-binding properties of the Praja-1 protein and also its E3 ubiquitin-protein ligase action.

General description

18:0-22:6 PG or 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phospho-(1′-rac-glycerol) is a sodium salt of glycerophospholipid, with substitution of stearic acid, docosahexaenic acid and phospho-rac-(1-glycerol) at the sn-1, sn-2 and sn-3 positions respectively, in the glycerol backbone.

Packaging

5 mL Clear Glass Sealed Ampule (840506C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk

WGK 3

法规信息

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分析证书(COA)

Lot/Batch Number

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Ju Yong Lee et al.
Journal of chromatography. A, 1288, 54-62 (2013-03-26)
Oxidized low density lipoproteins (Ox-LDLs) have an important role in the development of age-related vascular disease, such as atherosclerosis. Ox-LDLs are defined as oxidatively modified LDLs in the blood by enzymatic or non-enzymatic oxidation of phospholipids (PLs). For the characterization
Qiang Lu et al.
FEBS letters, 594(11), 1787-1796 (2020-03-07)
Serotonin transporter (SERT) is involved in serotonergic system regulation and in the pathophysiology/therapeutics of serotonin-/SERT-related diseases such as obsessive-compulsive disorder, depression, autism, and schizophrenia. We recently revealed that diacylglycerol (DG) kinase (DGK) δ induces ubiquitination/degradation of SERT in a DGK

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