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Merck
CN

840512C

Avanti

16:0 Phosphatidylethanol

Avanti Research™ - A Croda Brand

别名:

1,2-dihexadecanoyl-sn-glycero-3-phosphoethanol (sodium salt)

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关于此项目

经验公式（希尔记法）:
C37H72O8PNa
化学文摘社编号:
92609-90-0
分子量:
698.93
MDL number:
MFCD32697031
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

16:0 Phosphatidylethanol, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanol (sodium salt), chloroform

SMILES string

[H][C@@](COP([O-])(OCC)=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C37H73O8P.Na/c1-4-7-9-11-13-15-17-19-21-23-25-27-29-31-36(38)42-33-35(34-44-46(40,41)43-6-3)45-37(39)32-30-28-26-24-22-20-18-16-14-12-10-8-5-2;/h35H,4-34H2,1-3H3,(H,40,41);/q;+1/p-1/t35-;/m1./s1

InChI key

MAGNEPCJIVJZIK-RUQJKXHKSA-M

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840512C-25mg), pkg of 1 × 20 mL (840512C-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840512C

concentration

10 mg/mL (840512C-25mg), 25 mg/mL (840512C-500mg)

shipped in

dry ice

storage temp.

−20°C

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General description

Phosphatidylethanol (PEth) is an abnormal phospholipid found in the cellular membrane. It is spotted in the liver, skeletal muscle, brain and kidney of rat when its mainly exposed to ethanol. 16:0 Phosphatidylethanol/(1,2-dipalmitoyl-sn-glycero-3-phosphoethanol) has two palmitic acid chains.

Application

16:0 Phosphatidylethanol (Peth)/(1,2-dipalmitoyl-sn-glycero-3-phosphoethanol) may be used:
  • as an internal standard in liquid chromatography−mass spectrometry (LC-MS) analysis of PEth in human whole blood
  • as an internal standard to spike blood samples for in liquid chromatography high-resolution mass spectrometry (LC−HRMS) analysis
  • as a standard in calibration curve generation and validation of ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-ESI-MS/MS)

Biochem/physiol Actions

Phosphatidylethanol can be used as a biomarker in blood for chronic alcohol use.

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (840512C-500mg)
5 mL Clear Glass Sealed Ampule (840512C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

易制毒化学品（2类）
危险化学品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Guido Viel et al.
International journal of molecular sciences, 13(11), 14788-14812 (2012-12-04)
The present paper aims at a systematic review of the current knowledge on phosphatidylethanol (PEth) in blood as a direct marker of chronic alcohol use and abuse. In March 2012, the search through "MeSH" and "free-text" protocols in the databases
Alessandro Nalesso et al.
Journal of chromatography. A, 1218(46), 8423-8431 (2011-10-18)
Phosphatidylethanol (PEth) is a group of aberrant phospholipids formed in cell membranes in the presence of ethanol by the catalytic action of the enzyme phospholipase D on phosphatidylcholine. Recently published literature has demonstrated the existence of several molecular species of
Siming Wang et al.
Talanta, 166, 315-320 (2017-02-19)
Phosphatidylethanol (PEth) is a special phospholipid that is only formed in the presence of ethanol, and therefore, serves as a promising biomarker for alcohol intake. In this study, a simple, rapid and precise method based on LC-MS/MS combined with ultrasound-assisted
Natalie Kummer et al.
Analytical and bioanalytical chemistry, 408(3), 825-838 (2015-11-26)
Phosphatidylethanol species (PEths) are promising biomarkers of alcohol consumption. Here, we report on the set-up, validation, and application of a novel UHPLC-ESI-MS/MS method for the quantification of PEth 16:0/18:1, PEth 18:1/18:1, and PEth 16:0/16:0 in whole blood (30 μL) and

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