产品名称
18:1 Phosphatidylethanol, 1,2-dioleoyl-sn-glycero-3-phosphoethanol (sodium salt), powder
SMILES string
[H][C@@](COP([O-])(OCC)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]
InChI
1S/C41H77O8P.Na/c1-4-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-40(42)46-37-39(38-48-50(44,45)47-6-3)49-41(43)36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-5-2;/h19-22,39H,4-18,23-38H2,1-3H3,(H,44,45);/q;+1/p-1/b21-19-,22-20-;/t39-;/m1./s1
InChI key
AHVVHDCFEFPKMN-AOEFFCPUSA-M
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 25 mg (840513P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 840513P
shipped in
dry ice
storage temp.
−20°C
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General description
18:1 Phosphatidylethanol (PEth)/1,2-dioleoyl-sn-glycero-3-phosphoethanol is a sodium salt of modified lipid, wherein C-1, C-2 of glycerol is substituted with 9Z-octadecenolyl and C-3 of glycerol is substituted by phosphoethanol group. This lipid metabolite of ethanol has two oleic acid chains.
Application
18:1 Phosphatidylethanol (PEth)/1,2-dioleoyl-sn-glycero-3-phosphoethanol may be used:
- as a standard in liquid chromatography−mass spectrometry (LC-MS) analysis of PEth in human whole blood
- as a reference material in quantifying phosphatidylethanol in human blood by liquid chromatography high resolution mass spectrometry (LC−HRMS )
- to incorporate into human high density lipoprotein (HDL) particles to study its effects on the secretion of vascular endothelial growth factor (VEGF) in cultured human smooth muscle cells
Biochem/physiol Actions
Phosphatidylethanol (PEth) obtained from phosphatidylcholine in erythrocytes can acts as an important biomarker for alcohol consumption.
Packaging
5 mL Clear Glass Sealed Ampule (840513P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Marja K Liisanantti et al.
Atherosclerosis, 180(2), 263-269 (2005-05-25)
To study whether qualitative changes in high density lipoprotein (HDL) phospholipids mediate part of the advantageous effects of ethanol on atherosclerosis, we investigated whether HDL associated phosphatidylethanol (PEth) affects the secretion of vascular endothelial growth factor (VEGF) from cultured human
Xiaoyu Liang et al.
Molecular psychiatry (2020-02-09)
The process of diagnosing hazardous alcohol drinking (HAD) is based on self-reported data and is thereby vulnerable to bias. There has been an interest in developing epigenetic biomarkers for HAD that might complement clinical assessment. Because alcohol consumption has been
Alessandro Nalesso et al.
Journal of chromatography. A, 1218(46), 8423-8431 (2011-10-18)
Phosphatidylethanol (PEth) is a group of aberrant phospholipids formed in cell membranes in the presence of ethanol by the catalytic action of the enzyme phospholipase D on phosphatidylcholine. Recently published literature has demonstrated the existence of several molecular species of
Siming Wang et al.
Talanta, 166, 315-320 (2017-02-19)
Phosphatidylethanol (PEth) is a special phospholipid that is only formed in the presence of ethanol, and therefore, serves as a promising biomarker for alcohol intake. In this study, a simple, rapid and precise method based on LC-MS/MS combined with ultrasound-assisted
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