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关于此项目
经验公式（希尔记法）:
C45H90N2O16P2
化学文摘社编号:
分子量:
977.15
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
18:1 PI(5)P, 1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-5′-phosphate) (ammonium salt), powder
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (850152P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850152P-500ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 850152P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
Application
18:1 PI（11）P（1，2-二油酰基-sn-甘油-3-磷酸-（1′-肌醇-5′-磷酸）（铵盐））已用于蛋白质−脂质覆盖测定。它可以用于脂质体制备，并用于脂质体下拉实验的脂质体制备。
Biochem/physiol Actions
已知5-磷酸磷脂酰肌醇（PI5P）可控制染色质的组织和基因表达。它也可以作为肌动蛋白细胞骨架、膜运输和信号传导的协调者。它参与自噬。
General description
18:1 PI（11）P（1，2-二油酰基-sn-甘油-3-磷酸-（1′-肌醇-5′-磷酸））是修饰脂质的铵盐。哺乳动物细胞中约0.5%的总磷酸肌醇（PI）由PI5P组成。
肌醇磷脂物质是膜结合的信号分子，它参与细胞生理学的几乎所有方面，包括细胞生长、代谢、增殖和存活。
Packaging
带塞子和压接盖的2 mL棕色血清瓶（850152P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850152P-500ug）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Divyanshu Mahajan et al.
Nature communications, 10(1), 3218-3218 (2019-07-22)
Proteins are transported among eukaryotic organelles along the cytoskeleton in membrane carriers. The mechanism regarding the motility of carriers and the positioning of organelles is a fundamental question in cell biology that remains incompletely understood. Here, we find that Dopey1
Chao-Yuan Yu et al.
Plant physiology, 183(1), 221-235 (2020-03-25)
Phosphoinositides function as lipid signals in plant development and stress tolerance by binding with partner proteins. We previously reported that Arabidopsis (Arabidopsis thaliana) phosphoinositide-specific phospholipase C2 functions in the endoplasmic reticulum (ER) stress response. However, the underlying molecular mechanisms of
Anbang Dai et al.
Nature communications, 10(1), 3699-3699 (2019-08-20)
WHAMM, a member of the Wiskott-Aldrich syndrome protein (WASP) family, is an actin nucleation promoting factor (NPF) that also associates with membranes and microtubules. Here we report that WHAMM is required for autophagic lysosome reformation (ALR). WHAMM knockout causes impairment
Frédéric Boal et al.
Journal of cell science, 128(4), 815-827 (2015-01-16)
Phosphoinositides represent a major class of lipids specifically involved in the organization of signaling cascades, maintenance of the identity of organelles and regulation of multiple intracellular trafficking steps. We previously reported that phosphatidylinositol 5-monophosphate (PI5P), produced by the Shigella flexneri
Junya Hasegawa et al.
Cell structure and function, 42(1), 49-60 (2017-03-18)
In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions. Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) are extremely low relative to some other PIs, emerging evidence demonstrates that both lipids are crucial
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