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Merck
CN

850182P

Avanti

08:0 PI(4)P

Avanti Research - A Croda Brand

别名:

PIP[4′](8:0/8:0)

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关于此项目

经验公式(希尔记法):
C25H54N2O16P2
化学文摘社编号:
分子量:
700.65
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
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产品名称

08:0 PI(4)P, Avanti Research - A Croda Brand

InChI

1S/C25H48O16P2.2H3N/c1-3-5-7-9-11-13-18(26)37-15-17(39-19(27)14-12-10-8-6-4-2)16-38-43(35,36)41-25-22(30)20(28)24(21(29)23(25)31)40-42(32,33)34;;/h17,20-25,28-31H,3-16H2,1-2H3,(H,35,36)(H2,32,33,34);2*1H3/t17-,20-,21+,22-,23-,24+,25+;;/m1../s1

InChI key

GRYUDEZZGXKOJR-JHABFHEXSA-N

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+]

description

1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′-phosphate) (ammonium salt)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850182P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850182P-500ug))

manufacturer/tradename

Avanti Research - A Croda Brand

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

Application

08:0 PIP已用于制备用于脂质结合测定的多层囊泡脂质体(MLV)。它还适用于形成蛋白质-脂质管,并检查荧光光谱以分析Osh1 OSBP相关结构域(ORD)的PIP/固醇交换性质

Biochem/physiol Actions

08:0 PIP可以控制离子通道活性。具有短酰基链的磷酸肌醇磷酸酯(PIP)可溶于水,可用于可逆转运到质膜中。

General description

08:0 PIP是一种磷酸肌醇磷酸盐(PIP)。在原核生物中,PI是由分枝杆菌和其他细菌属合成的。
肌醇磷脂物质是膜结合的信号分子,它参与细胞生理学的几乎所有方面,包括细胞生长、代谢、增殖和存活。

Packaging

带塞子和压接盖的2 mL棕色血清瓶(850182P-100ug)
带塞子和压接盖的2 mL棕色血清瓶(850182P-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling
Sundborger A, et al.
Journal of Cell Science, 124(1), 133-143 (2011)
Intracellular traffic of the lysine and glutamic acid rich protein KERP1 reveals features of endomembrane organization in Entamoeba histolytica
Perdomo D, et al.
Cellular Microbiology, 18(8), 1134-1152 (2016)
Structure of yeast OSBP-related protein Osh1 reveals key determinants for lipid transport and protein targeting at the nucleus-vacuole junction
Manik MK, et al.
Structure, 25(4), 617-629 (2017)
Short-chain phosphoinositide partitioning into plasma membrane models
Collins MD and Gordon SE
Biophysical Journal, 105(11), 2485-2494 (2013)
Ke Wang et al.
The Journal of biological chemistry, 287(45), 37964-37972 (2012-09-15)
Macroautophagy (hereafter autophagy) is a degradative cellular pathway that protects eukaryotic cells from stress, starvation, and microbial infection. This process must be tightly controlled because too little or too much autophagy can be deleterious to cellular physiology. The phosphatidylinositol (PtdIns)

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