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Merck
CN

850185P

Avanti

08:0 PI (4,5) P2

Avanti Research™ - A Croda Brand

别名:

PIP2[4′,5′](8:0/8:0); 110665

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关于此项目

经验公式（希尔记法）:
C25H58N3O19P3
化学文摘社编号:
852043-37-9
分子量:
797.66
UNSPSC Code:
51191904
NACRES:
NA.25

主要文件

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产品名称

08:0 PI (4,5) P2, Avanti Research™ - A Croda Brand

InChI

1S/C25H49O19P3.3H3N/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36;;;/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36);3*1H3/t17-,20-,21+,22+,23-,24-

InChI key

FRWPUPUJRUQWKA-OZTQGENFSA-N

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+]

description

1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850185P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850185P-500ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

相关类别

Application

08:0 PI(4,5)P2适用于识别瞬时受体电位香草酸4（TRPV4 N）末端的结合位点。它可用于体外结合试验，以测定G蛋白偶联受体激酶（GRK）和β2肾上腺素能受体（β2AR）的结合。

General description

尽管PI(4,5)P2是细胞膜的次要成分，但它作为许多重要信号转导蛋白的底物发挥着重要作用。PI(4,5)P2是IP3/DAG途径中的中间体，在该途径中，它被磷脂酶C水解，释放第二信使，即肌醇1,4,5-三磷酸（IP3）和二酰基甘油（DAG）。PI(4,5)P2也是PI 3-激酶的底物，可被磷酸化为PI(3,4,5)P3，后者是下游信号转导成分（如蛋白激酶AKT）的激活剂。PI(4,5)P2的二辛酰基衍生物比其长链对应物更易溶于水。

Packaging

带塞子和压接盖的2 mL棕色血清瓶（850185P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850185P-500ug）

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP2
Goretzki B, et al.
Structure, 26(12), 1583-1593 (2018)
Peter Y Mercredi et al.
Journal of molecular biology, 428(8), 1637-1655 (2016-03-20)
Assembly of HIV-1 particles is initiated by the trafficking of viral Gag polyproteins from the cytoplasm to the plasma membrane, where they co-localize and bud to form immature particles. Membrane targeting is mediated by the N-terminally myristoylated matrix (MA) domain
Tao Liang et al.
The Journal of biological chemistry, 289(9), 6028-6040 (2014-01-17)
In β-cells, syntaxin (Syn)-1A interacts with SUR1 to inhibit ATP-sensitive potassium channels (KATP channels). PIP2 binds the Kir6.2 subunit to open KATP channels. PIP2 also modifies Syn-1A clustering in plasma membrane (PM) that may alter Syn-1A actions on PM proteins
Structural and functional analysis of a beta2-adrenergic receptor complex with GRK5
Komolov KE, et al.
Cell, 169(3), 407-421 (2017)
Scott B Hansen et al.
Nature, 477(7365), 495-498 (2011-08-30)
The regulation of ion channel activity by specific lipid molecules is widely recognized as an integral component of electrical signalling in cells. In particular, phosphatidylinositol 4,5-bisphosphate (PIP(2)), a minor yet dynamic phospholipid component of cell membranes, is known to regulate
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