产品名称
18:3 (Cis) PC, Avanti Research™ - A Croda Brand 850395C
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 2.5 mL (850395C-25mg), pkg of 2 × 4 mL (850395C-200mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850395C
concentration
10 mg/mL (850395C-25mg), 25 mg/mL (850395C-200mg)
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
General description
18:3 (cis) PC or 1,2-dilinolenoyl-sn-glycero-3-phosphocholine is an unsaturated glycerophospholipid, with substitution of two chains of linolenic acid at sn-1 and sn-2 positions of the glycerol backbone, along with choline as a headgroup.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
Application
18:3 (cis) PC or 1,2-dilinolenoyl-sn-glycero-3-phosphocholine:
- might be used in aqueous lipid-trehalose formulations to assess the long-term storage stability of lyophilized liposomes
- might be used in phospholipid monolayer to study the instability of unsaturated phospholipids at specified conditions
- has been used in aqueous sugar formulations or liposome formulations to characterize its degradation during lyophilization
Packaging
5 mL Clear Glass Sealed Ampule (850395C-200mg)
5 mL Clear Glass Sealed Ampule (850395C-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
wgk
WGK 3
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
危险化学品
易制毒化学品（2类）
此项目有
N M Payton et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 85(2), 306-313 (2013-04-10)
As liquid liposomal formulations are prone to chemical degradation and aggregation, these formulations often require freeze drying (e.g., lyophilization) to achieve sufficient shelf-life. However, liposomal formulations may undergo oxidation during lyophilization and/or during prolonged storage. The goal of the current
Jonathan F D Liljeblad et al.
Biophysical journal, 98(10), L50-L52 (2010-05-21)
The surface specific technique vibrational sum frequency spectroscopy has been applied to in situ studies of the degradation of Langmuir monolayers of 1,2-diacyl-phosphocholines with various degrees of unsaturation in the aliphatic chains. To monitor the degradation of the phospholipids, the
Nicole M Payton et al.
Journal of pharmaceutical sciences, 103(12), 3869-3878 (2014-10-14)
Because aqueous liposomal formulations containing multiply unsaturated lipids are susceptible to chemical degradation, these formulations are often lyophilized. Despite their limited chemical stability, interest in the use of multiply unsaturated lipids to promote intracellular delivery has increased considerably in recent
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