产品名称
Facade™-TEG, 3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane, powder
方案
>99% (TLC)
表单
powder
分子量
997.17 g/mol
包装
pkg of 1 × 25 mg (850538P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 850538P
技术
protein quantification: suitable
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@]12[C@]([C@](CC[C@@H](OCCO[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C4)(C)[C@]4([H])C[C@H]2OCCO[C@@H]5[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O5)([H])C[C@H](OCCO[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@]7(C)[C@@]1([H])CC[C@@H]7[C@H](C)CCC
一般描述
Facade™ TEG/FA-5 (3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane) carries three sugar (maltoside/glucoside) attachments on the steroid backbone.
生化/生理作用
Facade™ TEG/FA-5 (3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane), a sugar-based facial amphiphile can be used in membrane protein (MP) crystallization experiments. Facade-TEG helps to enhance the thermostability of type II cannabinoid receptor (CB2). Facade detergents acts as the best platform for biophysical characterization of G protein-coupled receptor (GPCR).
包装
5 mL Amber Glass Screw Cap Vial (850538P-25mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Facade is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
法规信息
新产品
此项目有
Ryan L Beckner et al.
The Journal of biological chemistry, 295(1), 181-190 (2019-11-30)
G protein-coupled receptors (GPCRs) comprise a large class of integral membrane proteins involved in the regulation of a broad spectrum of physiological processes and are a major target for pharmaceutical drug development. Structural studies can help advance the rational design
Sung Chang Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(13), E1203-E1211 (2013-03-13)
Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We have developed a family of steroid-based facial amphiphiles (FAs) that are structurally distinct from conventional detergents and previously developed FAs. The unique FAs stabilize MPs and
Designing facial amphiphiles for the stabilization of integral membrane proteins.
Qinghai Zhang et al.
Angewandte Chemie (International ed. in English), 46(37), 7023-7025 (2007-08-11)
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