description
1-arachidoyl-2-hydroxy-sn-glycero-3-phosphocholine, chloroform
assay
>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)
form
liquid
packaging
pkg of 1 × 2.5 mL (855777C-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
10 mg/mL (855777C-25mg)
shipped in
dry ice
storage temp.
−20°C
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General description
Lysophosphatidylcholine (Lyso-PC) is a component of blood plasma, vascular tissue and lipoproteins.
Application
20:0 Lyso PC has been used as an internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) to quantify very long chain fatty acids (VLCFA) levels in peroxisome biogenesis disorders (PBD) cell lines.
Biochem/physiol Actions
Lysophosphatidylcholine (Lyso-PC) is associated with inflammatory diseases and atherosclerosis. It stimulates the expression of genes for growth factors and cellular adhesion molecules.
Packaging
5 mL Clear Glass Sealed Ampule (855777C-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
易制毒化学品（2类）
危险化学品
此项目有
The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders
Law KB, et al.
Autophagy, 13(5), 868-884 (2017)
Development and validation of a UHPLC-ESI-MS/MS method for the simultaneous quantification of mammal lysophosphatidylcholines and lysophosphatidylethanolamines in serum
Suarez-Garcia S, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1055, 86-97 (2017)
Lysophosphatidylcholine stimulates the release of arachidonic acid in human endothelial cells
Wong JT, et al.
Test, 273(12), 6830-6836 (1998)
Kelsey B Law et al.
Autophagy, 13(5), 868-884 (2017-05-20)
Peroxisome biogenesis disorders (PBDs) are metabolic disorders caused by the loss of peroxisomes. The majority of PBDs result from mutation in one of 3 genes that encode for the peroxisomal AAA ATPase complex (AAA-complex) required for cycling PEX5 for peroxisomal
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