产品名称
VPC 23019, Avanti Research™ - A Croda Brand 857360P, powder
SMILES string
CCCCCCCCC1=CC(NC([C@H]([NH3+])COP(O)([O-])=O)=O)=CC=C1
InChI
1S/C17H29N2O5P/c1-2-3-4-5-6-7-9-14-10-8-11-15(12-14)19-17(20)16(18)13-24-25(21,22)23/h8,10-12,16H,2-7,9,13,18H2,1H3,(H,19,20)(H2,21,22,23)/t16-/m1/s1
InChI key
MRUSUGVVWGNKFE-MRXNPFEDSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (857360P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857360P
lipid type
cardiolipins
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
VPC 23019是一种芳基酰胺化合物。它是1-磷酸鞘氨醇（S1P）的类似物。
Application
VPC 23019可用于：
- 基于水母发光蛋白的Ca2+检测
- 分析1-磷酸鞘氨醇（S1P）诱导的纤溶酶原激活物抑制剂1（PAI-1）表达的调节作用
- 逆转脂多糖（LPS）处理的小鼠体内载脂蛋白M过表达的保护作用
Biochem/physiol Actions
VPC 23019是鞘氨醇-1-磷酸-1（S1P1）和S1P3受体的竞争性拮抗剂。
Packaging
5 mL棕色玻璃螺旋盖样品瓶（857360P-1mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Sphingosine 1-phosphate analogs as receptor antagonists
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The Journal of biological chemistry, 280(11) (2005)
Vehicle-dependent effects of sphingosine 1-phosphate on plasminogen activator inhibitor-1 expression
Takahashi C, et al.
Journal of Atherosclerosis and Thrombosis, 37663-37663 (2017)
Apolipoprotein M protects lipopolysaccharide-treated mice from death and organ injury
Kurano M, et al.
Thrombosis and Haemostasis, 118(06) (2018)
A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca2+ microdomain in the caveolar compartment
Pulli I, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1853(9) (2015)
Eun-Young Kim et al.
Cells, 9(1) (2020-01-16)
The interleukin-22 (IL-22) signaling pathway is well known to be involved in the progression of various cancer types but its role in bone metastatic breast cancer remains unclear. We demonstrate using human GEO profiling that bone metastatic breast cancer displays
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