产品名称
VPC 23153, Avanti Research™ - A Croda Brand 857367P, powder
SMILES string
CCCCCCCCC1=CC=C2C(N=C([C@H](COP(O)([O-])=O)[NH3+])N2)=C1
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (857367P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857367P
shipped in
dry ice
storage temp.
−20°C
Application
VPC 23153 has been used to study its effects in isolated pulmonary, renal and mesenteric arteries. It has also been used to study its pharmacological properties at the human sphingosine 1-phosphate 3 (S1P3)receptor expressed in Chinese hamster ovary (CHO) FlpIn cells.
Biochem/physiol Actions
VPC 23153 is a sphingosine 1-phosphate 4 (S1P4) receptor agonist. It is associated with the contraction of pulmonary arteries in rats.
Packaging
5 mL Amber Glass Screw Cap Vial (857367P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
Hiroki Ota et al.
Pulmonary circulation, 1(3), 399-404 (2011-12-06)
This study aimed to identify receptors mediating sphingosine-1-phosphate (S1P)-induced vasoconstriction in the normotensive and chronic hypoxia-induced hypertensive rat pulmonary circulation. In isolated perfused lungs from normoxic rats, infusion of S1P caused a sustained vasoconstriction, which was not reduced by combinational
M Jongsma et al.
British journal of pharmacology, 156(8), 1305-1311 (2009-03-25)
Recently, some ligands targeting the sphingosine-1-phosphate receptor subtype 3 (S1P(3)) have become available. The characterization of these compounds was mainly based on one functional read-out system, although S1P(3) receptors are known to activate different signal transduction pathways. Therefore, this study
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