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Merck
CN

860058P

Avanti

单唾液神经节苷酯 GM3 (牛乳)

Avanti Research™ - A Croda Brand

别名:

110953

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关于此项目

化学文摘社编号:
1246353-19-4
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

单唾液神经节苷酯 GM3 (牛乳), Avanti Research™ - A Croda Brand

InChI

1S/C59H108N2O21.H3N/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-46(69)61-40(41(66)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)38-77-56-51(73)50(72)53(45(37-64)79-56)80-57-52(74)55(49(71)44(36-63)78-57)82-59(58(75)76)34-42(67)47(60-39(3)65)54(81-59)48(70)

InChI key

WFQOHDPRXSLGNK-BLVJLEROSA-N

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O)[C@@H](CO)O1.[NH4+]

description

GM3 Ganglioside (Milk, Bovine-Ammonium Salt)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (860058P-1mg)
pkg of 1 × 10 mg (860058P-10mg)
pkg of 1 × 25 mg (860058P-25mg)
pkg of 1 × 5 mg (860058P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

相关类别

Application

神经节苷脂 GM3（牛乳）用于脂质结合测定，评估单克隆抗体（mAb）的结合情况。可作为标准品，用电喷雾电离质谱（ESI MS）分析研究脑中神经节苷脂的提取效率。也可用于通过紫外光致解离质谱，确定神经节苷脂的结构表征。

Biochem/physiol Actions

神经节苷脂单唾液酸二己糖神经节苷脂（GM3）阻断成纤维细胞生长因子受体的活性。富含GM3的微结构域参与调控细胞生长。神经节苷脂GM3水平低与类风湿关节炎的发病机制有关。GM3通过阻止细胞因子产生，调节免疫功能。能调节细胞凋亡、细胞增殖和细胞分化。GM3还参与细胞信号通路、细胞粘附和细胞迁移。GM3水平升高与糖尿病肾病有关。

General description

神经节苷脂单唾液酸二己糖基神经节苷脂（GM3）是糖鞘脂（GSL），为膜结合型，由唾液酸残基和寡糖头部结构组成。存在于牛乳和肾脏细胞中。GM3是组织中分布最广的神经节苷脂。

Packaging

5 mL棕色玻璃螺旋盖瓶 (860058P-10mg)
5 mL棕色玻璃螺旋盖瓶 (860058P-1mg)
5 mL棕色玻璃螺旋盖瓶 (860058P-25mg)
5 mL棕色玻璃螺旋盖瓶 (860058P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

法规信息

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John P O'Brien et al.
Analytical chemistry, 85(21), 10399-10407 (2013-10-03)
Ultraviolet photodissociation (UVPD) mass spectrometry was used to characterize the structures of amphiphilic glycosphingolipids and gangliosides in comparison to collision induced dissociation (CID) and higher energy collision dissociation (HCD) in a high performance Orbitrap mass spectrometer. UVPD produced the widest
Igor Vukovic et al.
Kidney & blood pressure research, 40(3), 306-314 (2015-06-06)
Despite scientific advances, diabetic nephropathy remains both a therapeutical challenge, and one of the major diabetic complications. Chemical structure of gangliosides, the most complex of glycosphingolipids, is characterised by one or more sialic acids and carbohydrate groups linked to a
Yukinori Tsukuda et al.
PloS one, 7(6), e40136-e40136 (2012-07-07)
Rheumatoid arthritis (RA), a chronic systemic inflammatory disorder that principally attacks synovial joints, afflicts over 2 million people in the United States. Interleukin (IL)-17 is considered to be a master cytokine in chronic, destructive arthritis. Levels of the ganglioside GM3
Sonia Tomar et al.
Glycoconjugate journal (2019-12-06)
Sialidases or neuraminidases play important roles in various physiological and pathological processes by cleaving terminal sialic acids (Sias) (desialylation) from the glycans of both glycoproteins and glycolipids. To understand the biological significance of desialylation by sialidases, it is important to
Thomas Kolter
ISRN biochemistry, 2012, 506160-506160 (2012-01-01)
Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence
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