Product Name
1-desoxymethylsphinganine, Avanti Research™ - A Croda Brand 860473P, powder
表单
powder
包装
pkg of 1 × 1 mg (860473P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860473P
脂质类型
bioactive lipids
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
NC[C@]([H])(O)CCCCCCCCCCCCCCC
InChI key
UGVBFHUWZNNKIK-QGZVFWFLSA-N
一般描述
1-desoxymethylsphinganine is synthesized by the condensation of alanine with palmitoyl-CoA.
应用
1-desoxymethylsphinganine is suitable for use for testing its cytotoxic effects on primary neuron-glia cultures. It is also suitable for use as a neurotoxic agent in human CD8+ T cells. In hereditary sensory and autonomic neuropathy type I, mutations in serine palmitoyltransferase long chain base subunit 1 resulting in altered substrate specificity and accumulation of 1.
生化/生理作用
1-desoxymethylsphinganine is neurotoxic towards CD8+ T cells and inhibits cytokine production. However, it is not cytotoxic to dopaminergic neurons.
包装
5 mL Amber Glass Screw Cap Vial (860473P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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