Product Name
1-desoxymethylsphingosine, 1-desoxymethylsphingosine (m17:1), powder
表单
powder
包装
pkg of 1 × 1 mg (860477P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 860477P
脂质类型
sphingolipids
bioactive lipids
运输
dry ice
储存温度
−20°C
SMILES字符串
CCCCCCCCCCCCC/C=C/[C@](O)([H])CN
InChI
1S/C17H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(19)16-18/h14-15,17,19H,2-13,16,18H2,1H3/b15-14+/t17-/m1/s1
InChI key
NTZGVZKEAIALQE-IAOULYHDSA-N
一般描述
1-desoxymethylsphingosine is synthesized from glycine in the presence of the enzyme serine palmitoyltransferase (SPT).
应用
1-desoxymethylsphingosine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line.
生化/生理作用
1-desoxymethylsphingosine is less neurotoxic compared to 1-desoxysphingosine in dorsal root ganglion neuronscultures Mutations in the palmitoyltransferase (SPT) in hereditary sensory neuropathy type 1 (HSAN-1), due to altered substrate specificity 1-desoxymethylsphinganine and 1-deoxy-sphinganine which are further converted to -deoxy(methyl)-ceramide and 1-deoxy(methyl)-sphingosine (1-deoxy(methyl)-SO). However, they lack the hydroxyl group essential for glycosphingolipid generation, resulting in accumulation of intermediate products.
包装
5 mL Amber Glass Screw Cap Vial (860477P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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