SMILES string
OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1
InChI key
WWUZIQQURGPMPG-KRWOKUGFSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860490P-10mg), pkg of 1 × 25 mg (860490P-25mg), pkg of 1 × 500 mg (860490P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
鞘氨醇 (d18:1) 是存在于动植物中的一种鞘氨醇骨架。它具有2-氨基-1,3-二醇官能团，并且其较难从动物组织中进行提取。 鞘氨醇 (d18:1) 可由D-半乳糖通过手性方法进行合成。
Application
鞘氨醇 (d18:1) 已被用于：
- 小鼠鞘氨醇吸入研究中，以评估其在呼吸道上皮细胞中的治疗潜力
- 研究其对铜绿假单胞菌菌株的影响
- 作为液相色谱串联质谱法中的标准品，用于对表皮神经酰胺的定量
Biochem/physiol Actions
鞘氨醇（d18：1）对于包括细胞分化、生长和存活在内的生理过程至关重要。它可激活瞬态受体电位阳离子通道亚家族成员3（TRPM3）。
Packaging
20 mL透明玻璃螺旋盖小瓶（860490P-500mg）
5 mL琥珀色玻璃螺旋盖小瓶（860490P-10mg）
5 mL琥珀色玻璃螺旋盖小瓶（860490P-25mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Efficient Synthesis of d-erythro-Sphingosine and d-e rythro-Azidosphingosine from d-r ibo-Phytosphingosine via a Cyclic Sulfate Intermediate
Kim S, et al.
The Journal of Organic Chemistry, 71(22), 8661-8664 (2006)
Glucosylceramide critically contributes to the host defense of cystic fibrosis lungs
Kovacic B, et al.
Cellular Physiology and Biochemistry, 41(3), 1208-1218 (2017)
The total syntheses of D-erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine analog
Duclos Jr RI
Chemistry and Physics of Lipids, 111(2), 111-138 (2001)
Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic
Martin GE, et al.
Biochimie, 141, 91-96 (2017)
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
Wang Z, et al.
The Journal of Investigative Dermatology, 133(3), 668-676 (2013)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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