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Merck
CN

860496C

Avanti

Dimethyl Sphingosine (d18:1)

Avanti Research™ - A Croda Brand

别名:

N,N-dimethyl-D-erythro-sphingosine

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关于此项目

经验公式（希尔记法）:
C20H41NO2
化学文摘社编号:
119567-63-4
分子量:
327.55
UNSPSC代码:
12352211
NACRES:
NA.25

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产品名称

Dimethyl Sphingosine (d18:1), Avanti Research™ - A Croda Brand 860496C

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 1 mL (860496C-5mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 860496C

浓度

5 mg/mL (860496C-5mg)

脂质类型

sphingolipids

运输

dry ice

储存温度

−20°C

SMILES字符串

OC[C@@](N(C)C)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1

InChI key

YRXOQXUDKDCXME-YIVRLKKSSA-N

包装

5 mL Clear Glass Sealed Ampule (860496C-5mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

易制毒化学品（2类）
危险化学品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Hyo-Lim Kim et al.
Prostaglandins & other lipid mediators, 86(1-4), 18-25 (2008-03-05)
In the present study, we studied N,N-dimethyl-D-erythro-sphingosine (DMS)-induced cell death and its signaling mechanism in U937 human monocytes. We found that DMS induced cell death in a concentration-dependent manner, while sphingosine 1-phosphate did not. DMS also induced DNA fragmentation, nuclear
Juliana Fraga Vasconcelos et al.
Scientific reports, 7(1), 6171-6171 (2017-07-25)
Chagas disease cardiomyopathy is a parasite-driven inflammatory disease to which there are no effective treatments. Here we evaluated the therapeutic potential of N,N-dimethylsphingosine(DMS), which blocks the production of sphingosine-1-phosphate(S1P), a mediator of cellular events during inflammatory responses, in a model
Hyo-Lim Kim et al.
Prostaglandins & other lipid mediators, 86(1-4), 68-72 (2008-05-10)
Previously, we studied N,N-dimethyl-D-erythro-sphingosine (DMS)-induced cell death and signaling in U937 human monocytes; we found that DMS-induced sphingosine kinase- and PKC-independent apoptosis. In the present study, we studied apoptotic responses by three N-methyl derivatives of sphingosine: N-monomethyl-D-erythro-sphingosine (MMS), N,N,N-trimethyl-D-erythro-sphingosine (TMS)
Yup-Kyung Lee et al.
Molecules and cells, 23(1), 11-16 (2007-04-28)
N,N-dimethyl-D-erythro-sphingosine (DMS) is an N-methyl derivative of sphingosine and an inhibitor of protein kinase C (PKC) and sphingosine kinase (SK). In the present study, we examined the effects of DMS on intracellular Ca2+ concentration, pH, and glutamate uptake in human
L C Edsall et al.
Biochemistry, 37(37), 12892-12898 (1998-09-16)
Sphingosine 1-phosphate (SPP), a lipid second messenger formed by the action of sphingosine kinase, has been implicated in regulating diverse biological processes, including growth, survival, and differentiation. N,N-Dimethylsphingosine (DMS) inhibits sphingosine kinase and has been used to investigate the biological
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