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经验公式（希尔记法）:
C26H51NO3
化学文摘社编号:
分子量:
425.69
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C8 Ceramide (d18:1/8:0), Avanti Research™ - A Croda Brand 860508P, powder
SMILES string
OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C26H51NO3/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(29)24(23-28)27-26(30)22-20-17-8-6-4-2/h19,21,24-25,28-29H,3-18,20,22-23H2,1-2H3,(H,27,30)/b21-19+/t24-,25+/m0/s1
InChI key
APDLCSPGWPLYEQ-WRBRXSDHSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860508P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860508P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Application
C8 Ceramide (d18:1/8:0) has been used as an internal ceramide standard in electrospray ionization. It has also been used as a substrate for ceramide kinase activity assay. It is suitable for use as a substrate for galactocerebrosidase.
Biochem/physiol Actions
C8 Ceramide has anti-tumor functionality. Synthetic liposomal C8 ceramide inhibits hepatocellular carcinoma (HCC). Addition of exogenous C8 ceramide causes necrosis in hepatocytes by decreasing ATP levels and impairing mitochondrial functionality. C8 ceramide inhibition of serine palmitoyl transferase halts de novo sphingolipid biosynthesis. It also acts as chemotherapeutic agent by increasing the reactive oxygen species in lung cancer cells.
General description
C8 Ceramide is a short chain ceramide and is cell permeable.
Packaging
5 mL Amber Glass Screw Cap Vial (860508P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells
Chang Y, et al.
International Journal of Molecular Sciences, 19(10), 3010-3010 (2018)
Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat
Arora AS, et al.
Hepatology, 25(4), 958-963 (1997)
Preclinical evaluation of liposomal C8 ceramide as a potent anti-hepatocellular carcinoma agent
Lv H, et al.
Testing, 11(1), e0145195-e0145195 (2016)
The ORMDL/Orm-serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes
Davis DL, et al.
The Journal of Biological Chemistry, 294(13), 5146-5156 (2019)
Implementation of newborn screening for Krabbe disease: population study and cutoff determination
Orsini JJ, et al.
Clinical Biochemistry, 42(9), 877-884 (2009)
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