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Merck
CN

860519C

Avanti

C18:1 Ceramide (d18:1/18:1(9Z))

Avanti Research™ - A Croda Brand

别名:

N-oleoyl-D-erythro-sphingosine

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关于此项目

经验公式（希尔记法）:
C36H69NO3
化学文摘社编号:
5966-28-9
分子量:
563.94
UNSPSC Code:
12352211

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产品名称

C18:1 Ceramide (d18:1/18:1(9Z)), Avanti Research™ - A Croda Brand 860519C

InChI

1S/C36H69NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h17-18,29,31,34-35,38-39H,3-16,19-28,30,32-33H2,1-2H3,(H,37,40)/b18-17-,31-29+/t34-,35+/m0/s1

InChI key

OBFSLMQLPNKVRW-RHPAUOISSA-N

SMILES string

OC[C@]([H])(NC(CCCCCCC/C=C\CCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (860519C-5mg), pkg of 1 × 2.5 mL (860519C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860519C

concentration

10 mg/mL (860519C-25mg), 5 mg/mL (860519C-5mg)

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

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General description

C18:1 Ceramide (d18:1/18:1(9Z)) or N-oleoyl-D-erythro-sphingosine is a synthetic ceramide containing sphingosine with oleic acid.

Application

C18:1 Ceramide (d18:1/18:1(9Z)) or N-oleoyl-D-erythro-sphingosine has been used as a lipid standard in the optimization of the liquid chromatography-mass spectrometry (LC-MS) method conditions. It may be used as a standard to quantify ceramide content in muscle tissue samples using high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS2). It may also be used as a standard for the absolute quantification of epidermal lipids using liquid chromatography-tandem mass spectrometry (LC/MS/MS)

Packaging

5 mL Clear Glass Sealed Ampule (860519C-25mg)
5 mL Clear Glass Sealed Ampule (860519C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

易制毒化学品（2类）
危险化学品
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分析证书(COA)

Lot/Batch Number

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Meenu N Perera et al.
Biochimica et biophysica acta, 1818(5), 1291-1301 (2012-03-01)
The sphingolipid, ceramide, self-assembles in the mitochondrial outer membrane (MOM), forming large channels capable of translocating proteins. These channels are believed to be involved in protein release from mitochondria, a key decision-making step in cell death. Synthetic analogs of ceramide
Daniel A Peñalva et al.
Biochimica et biophysica acta, 1838(3), 731-738 (2013-12-10)
Unique species of ceramide (Cer) with very-long-chain polyunsaturated fatty acid (VLCPUFA), mainly 28-32 carbon atoms, 4-5 double bonds, in nonhydroxy and 2-hydroxy forms (n-V Cer and h-V Cer, respectively), are generated in rat spermatozoa from the corresponding sphingomyelins during the
Donato A Rivas et al.
Journal of applied physiology (Bethesda, Md. : 1985), 113(11), 1727-1736 (2012-10-09)
One of the most fundamental adaptive physiological events is the response of skeletal muscle to high-intensity resistance exercise, resulting in increased protein synthesis and ultimately larger muscle mass. However, muscle growth in response to contraction is attenuated in older humans.
Zhixing Wang et al.
The Journal of investigative dermatology, 133(3), 668-676 (2012-10-26)
The stratum corneum is composed of protein-enriched corneocytes embedded in an intercellular matrix of nonpolar lipids organized as lamellar layers and giving rise to epidermal permeability barrier (EPB). EPB defects have an important role in the pathophysiology of skin diseases
Max Lönnfors et al.
Langmuir : the ACS journal of surfaces and colloids, 29(7), 2319-2329 (2013-01-30)
We prepared cholesteryl phosphocholine (CholPC) by chemical synthesis and studied its interactions with small (ceramide and cholesterol) and large headgroup (sphingomyelin (SM) and phosphatidylcholine) colipids in bilayer membranes. We established that CholPC could form bilayers (giant uni- and multilamellar vesicles
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