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关于此项目
经验公式（希尔记法）:
C28H52N4O4S
化学文摘社编号:
分子量:
540.80
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
Biotin Sphingosine, Avanti Research™ - A Croda Brand 860550P, powder
SMILES string
[H][C@@]1(CCCCC(NCCCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@](N)([H])CO)=O)SC[C@@]2([H])[C@]1([H])NC(N2)=O
InChI
1S/C28H52N4O4S/c29-22(20-33)24(34)16-12-10-8-6-4-2-1-3-5-7-9-11-15-19-30-26(35)18-14-13-17-25-27-23(21-37-25)31-28(36)32-27/h12,16,22-25,27,33-34H,1-11,13-15,17-21,29H2,(H,30,35)(H2,31,32,36)/b16-12+/t22-,23-,24+,25-,27-/m0/s1
InChI key
NYQVYZZGZCNEMF-RPRIXWAOSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860550P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860550P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
Biotin Sphingosine is a derivative of sphingosine. It contains a biotin moiety linked to the ω-terminal of its fatty-acid chain.
Application
Biotin Sphingosine has been used as a substrate in sphingosine kinases (SphK) assay. It has also been used to label wt- ceramide synthase 1 (CerS1) expressed in UM-SCC-22A cells, to study the interaction between CerS1-generated C18-ceramide and light chain 3 β (LC3B).
Biochem/physiol Actions
Biotin Sphingosineplays a vital role in identifying sphingosine interaction with acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A).
Packaging
5 mL Amber Glass Screw Cap Vial (860550P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Bioactive Sphingolipids in Cancer Biology and Therapy (2015)
An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes
Roberts J, et al.
Analytical biochemistry, 331(1), 122-129 (2004)
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
Sentelle R, et al.
Nature Chemical Biology, 8(10), 831-831 (2012)
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