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经验公式（希尔记法）:
C32H65NO3
化学文摘社编号:
分子量:
511.86
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C14 dihydroceramide (d18:0/14:0), Avanti Research™ - A Croda Brand 860632P, powder
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C32H65NO3/c1-3-5-7-9-11-13-15-16-18-19-21-23-25-27-31(35)30(29-34)33-32(36)28-26-24-22-20-17-14-12-10-8-6-4-2/h30-31,34-35H,3-29H2,1-2H3,(H,33,36)/t30-,31+/m0/s1
InChI key
UDTSZXVRDXQARY-IOWSJCHKSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860632P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860632P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Application
C14 dihydroceramide has been used as a standard for measuring the concentration of sphingolipid metabolites in adipose tissues by quadrupole time-of-flight (Q-TOF) mass spectrometry.
General description
C14 dihydroceramide is a synthetic dihydroceramide. Acylation of sphinganine with myristoyl (FA-CoA with C14 acyl chain) by dihydro ceramide synthase 1, yields C14-dihydroceramide.
Packaging
5 mL Amber Glass Screw Cap Vial (860632P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Myristic acid increases the activity of dihydroceramide Delta4-desaturase 1 through its N-terminal myristoylation
Beauchamp E, et al.
Biochimie, 89(12), 1553-1561 (2007)
Erwan Beauchamp et al.
Biochimie, 89(12), 1553-1561 (2007-08-25)
Dihydroceramide Delta4-desaturase (DES) catalyzes the desaturation of dihydroceramide into ceramide. In mammals, two gene isoforms named DES1 and DES2 have recently been identified. The regulation of these enzymes is still poorly understood. This study was designed to examine the possible
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism
Mullen TD, et al.
Journal of Lipid Research, 52(1), 68-77 (2011)
Chain length-specific properties of ceramides
Grosch S, et al.
Progress in Lipid Research, 51(1), 50-62 (2012)
Thomas D Mullen et al.
Journal of lipid research, 52(1), 68-77 (2010-10-14)
Mammalian ceramide synthases 1 to 6 (CerS1-6) generate Cer in an acyl-CoA-dependent manner, and expression of individual CerS has been shown to enhance the synthesis of ceramides with particular acyl chain lengths. However, the contribution of each CerS to steady-state
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