产品名称
二甲基鞘氨醇(d17:1), Avanti Research™ - A Croda Brand, chloroform solution
SMILES string
OC[C@@](N(C)C)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCC
assay
99% (TLC)
form
chloroform solution
packaging
1 ea of 5 mg (860642C-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
Dimethyl Sphingosine is a derivative of sphingosine. It is found in many tissues.
Biochem/physiol Actions
Dimethyl Sphingosine plays a major role in the inhibition of protein kinase C (PKC) and sphingosine kinase. It is also involved in the inhibition of src kinase and augmentation of epidermal growth factor receptor (EGFR).
Packaging
5 mL Clear Glass Sealed Ampule
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Characterization of N, N,-dimethyl-d-erythro-sphingosine-induced apoptosis and signaling in U937 cells: Independence of sphingosine kinase inhibition
Kim H L, et al.
Prostaglandins & other lipid mediators, 86(1-4), 18-25 (2008)
N, N-Dimethyl-d-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes
Jo J Y, et al.
Journal of Pharmacological Sciences, 107(3), 303-307 (2008)
Tania C B Santos et al.
Langmuir : the ACS journal of surfaces and colloids, 36(21), 6007-6016 (2020-05-06)
Compared to the canonical sphingoid backbone of sphingolipids (SLs), atypical long-chain bases (LCBs) lack C1-OH (1-deoxy-LCBs) or C1-CH2OH (1-deoxymethyl-LCBs). In addition, when unsaturated, they present a cis-double bond instead of the canonical Δ4-5 trans-double bond. These atypical LCBs are directly
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