860642C
Avanti
二甲基鞘氨醇(d17:1)
Avanti Research™ - A Croda Brand
别名:
N,N-dimethyl-D-erythro-sphingosine (C17 base)
产品名称
二甲基鞘氨醇(d17:1), Avanti Research™ - A Croda Brand, chloroform solution
方案
99% (TLC)
表单
chloroform solution
包装
1 ea of 5 mg (860642C-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@@](N(C)C)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCC
一般描述
Dimethyl Sphingosine is a derivative of sphingosine. It is found in many tissues.
生化/生理作用
Dimethyl Sphingosine plays a major role in the inhibition of protein kinase C (PKC) and sphingosine kinase. It is also involved in the inhibition of src kinase and augmentation of epidermal growth factor receptor (EGFR).
包装
5 mL Clear Glass Sealed Ampule
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
N, N-Dimethyl-d-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes
Jo J Y, et al.
Journal of Pharmacological Sciences, 107(3), 303-307 (2008)
Characterization of N, N,-dimethyl-d-erythro-sphingosine-induced apoptosis and signaling in U937 cells: Independence of sphingosine kinase inhibition
Kim H L, et al.
Prostaglandins & other lipid mediators, 86(1-4), 18-25 (2008)
Tania C B Santos et al.
Langmuir : the ACS journal of surfaces and colloids, 36(21), 6007-6016 (2020-05-06)
Compared to the canonical sphingoid backbone of sphingolipids (SLs), atypical long-chain bases (LCBs) lack C1-OH (1-deoxy-LCBs) or C1-CH2OH (1-deoxymethyl-LCBs). In addition, when unsaturated, they present a cis-double bond instead of the canonical Δ4-5 trans-double bond. These atypical LCBs are directly
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