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Merck
CN

870708P

Avanti

辅酶 A，08:0

Avanti Research™ - A Croda Brand

别名:

辛酰辅酶A铵盐

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关于此项目

经验公式（希尔记法）:
C29H59N10O17P3S
CAS Number:
799812-82-1
分子量:
944.82
UNSPSC代码:
12352211
NACRES:
NA.25

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Product Name

辅酶 A，08:0, Avanti Research™ - A Croda Brand 870708P, powder

表单

powder

包装

pkg of 1 × 5 mg (870708P-5mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 870708P

应用

lipidomics

脂质类型

coenzymes

运输

dry ice

储存温度

−20°C

SMILES字符串

O[C@@](C(NCCC(NCCSC(CCCCCCC)=O)=O)=O)(C(C)(COP([O-])(OP([O-])(OC[C@H]([C@H]1OP([O-])(O)=O)O[C@H]([C@@H]1O)N2C3=C(C(N)=NC=N3)N=C2)=O)=O)C)[H].[NH4+].[NH4+].[NH4+]

InChI

1S/C29H50N7O17P3S.3H3N/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36;;;/h16-18,22-24,28,39-40H,4-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44);3*1H3/t18-,22?,23+,24+,28-;;;/m1.../s1

InChI key

FTIQWXKUZWNHGD-DMTDIVBASA-N

相关类别

一般描述

08:0辅酶A，又称辛酰基辅酶A，是一种中链酰基CoA。它是辛酸的辅酶A衍生物。

应用

08:0辅酶A已用作微粒体生长素释放肽辛酰基转移酶测定的底物。

生化/生理作用

08:0辅酶A充当线粒体脂肪酸β-氧化的中间体。它阻碍柠檬酸合成酶（CS）和谷氨酸脱氢酶（GDH）的活性。在患有MCADH缺乏症（MCD）的患者中，由于中链酰基辅酶A脱氢酶（MCADH）减少了辛酰基辅酶A的β-氧化作用，因此观察到较高水平的辛酰基辅酶A。

包装

5 mL棕色玻璃螺旋盖小瓶（870708P-5mg）

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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B A Amendt et al.
The Journal of clinical investigation, 76(3), 963-969 (1985-09-01)
Medium-chain acyl-coenzyme A (CoA) dehydrogenase (MCADH; EC 1.3.99.3) deficiency (MCD) is an inborn error of beta-oxidation. We measured 3H2O formed by the dehydrogenation of [2,3-3H]acyl-CoAs in a 3H-release assay. Short-chain acyl-CoA dehydrogenase (SCADH; EC 1.3.99.2), MCADH, and isovaleryl-CoA dehydrogenase (IVDH;
Robert Modre-Osprian et al.
BMC systems biology, 3, 2-2 (2009-01-08)
The oxidation of fatty acids in mitochondria plays an important role in energy metabolism and genetic disorders of this pathway may cause metabolic diseases. Enzyme deficiencies can block the metabolism at defined reactions in the mitochondrion and lead to accumulation
J C Lai et al.
Research communications in chemical pathology and pharmacology, 82(3), 331-338 (1993-12-01)
We investigated the hypothesis that one mechanism underlying fatty acid toxicity is the selective inhibition of rate-limiting and/or regulated tricarboxylic acid cycle and related enzymes by fatty acyl coenzyme A (CoA) derivatives by examining the effects of several fatty acyl
Martin S Taylor et al.
Bioorganic chemistry, 62, 64-73 (2015-08-08)
Ghrelin-O-Acyltransferase (GOAT) is an 11-transmembrane integral membrane protein that octanoylates the metabolism-regulating peptide hormone ghrelin at Ser3 and may represent an attractive target for the treatment of type II diabetes and the metabolic syndrome. Protein octanoylation is unique to ghrelin

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