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Merck
CN

880121C

Avanti

DSPE-PEG (2000)琥珀酰

Avanti Research™ - A Croda Brand

别名:

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[succinyl(polyethylene glycol)-2000] (ammonium salt)

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关于此项目

化学文摘社编号:
1445723-73-8
UNSPSC代码:
12352211
NACRES:
NA.25

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产品名称

DSPE-PEG (2000)琥珀酰, Avanti Research™ - A Croda Brand 880121C

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 1 mL (880121C-10mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 880121C

浓度

10 mg/mL (880121C-10mg)

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@@](COP([O-])(OCCNC(OCCOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO/C=C\N([H])C(CCC(O)=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=

一般描述

DSPE-PEG(2000) Succinyl is widely used in liposome preparation.
DSPE-PEG(2000) Succinyl or 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[succinyl(polyethylene glycol)-2000] is a functionalized PEG lipid.

应用

DSPE-PEG(2000) Succinyl has been used in micelle synthesis.
DSPE-PEG(2000) succinyl has been used to prepare PEGylated liposomes, to obtain sterically stabilized liposomes containing docetaxel. It has also been used in liposomes for vasoactive intestinal peptide (VIP) encapsulation, to achieve PEGylation.

包装

5 mL Clear Glass Sealed Ampule (880121C-10mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

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分析证书(COA)

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Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release
Schnorenberg MR, et al.
Materials, 12(16), 2567-2567 (2019)
Effects of poly (ethylene glycol)(PEG) concentration on the permeability of PEG-grafted liposomes
Hashizaki K, et al.
Chemical & Pharmaceutical Bulletin, 53(1), 27-31 (2005)
Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing docetaxel
Immordino ML, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 91(3), 417-429 (2003)
Two cholesterol derivative-based PEGylated liposomes as drug delivery system, study on pharmacokinetics and drug delivery to retina
Geng S, et al.
Nanotechnology, 25(27), 275103-275103 (2014)
Mathew R Schnorenberg et al.
Materials (Basel, Switzerland), 12(16) (2019-08-15)
Therapeutic manipulation of the BCL-2 family using BH3 mimetics is an emerging paradigm in cancer treatment and immune modulation. For example, peptides mimicking the BIM BH3 helix can directly target the full complement of anti- and pro-apoptotic BCL-2 proteins to

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