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Merck
CN

890895C

Avanti

18:1 TAP (DOTAP, MS Salt)

Avanti Research™ - A Croda Brand

别名:

1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt)

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关于此项目

经验公式（希尔记法）:
C43H83NO8S
化学文摘社编号:
144189-73-1
分子量:
774.19
MDL number:
MFCD16660441
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

18:1 TAP (DOTAP, MS Salt), Avanti Research™ - A Croda Brand 890895C

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.O=S([O-])(OC)=O

InChI

1S/C42H80NO4.CH4O4S/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;1-5-6(2,3)4/h20-23,40H,6-19,24-39H2,1-5H3;1H3,(H,2,3,4)/q+1;/p-1/b22-20-,23-21-;

InChI key

RSMRWWHFJMENJH-LQDDAWAPSA-M

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (890895C-25mg), pkg of 2 × 4 mL (890895C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 890895C

concentration

10 mg/mL (890895C-25mg), 25 mg/mL (890895C-200mg)

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

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Biochem/physiol Actions

DOTAP (1,2-dioleoyl-3-trimethylammonium-propane) is a cationic lipid, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP. DOTAP mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Packaging

5 mL Clear Glass Sealed Ampule (890895C-200mg)
5 mL Clear Glass Sealed Ampule (890895C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

易制毒化学品（2类）
危险化学品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Simberg D, et al.
Critical Reviews in Therapeutic Drug Carrier Systems, 21(4) (2004)
Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
Martino S, et al.
BioMed Research International, 2009 (2009)
DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes
Kim BK, et al.
Biochimica et Biophysica Acta - Biomembranes, 1848(10), 1996-2001 (2015)

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