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Merck
CN

890900O

Avanti

ALC-0315

Avanti Research™ - A Croda Brand

别名:

ALC 0315, 6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-aminium

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关于此项目

经验公式（希尔记法）:
C48H95NO5
分子量:
766.27
MDL number:
MFCD33402175
UNSPSC Code:
12352211
NACRES:
NA.25

主要文件

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InChI

1S/C48H95NO5/c1-5-9-13-17-19-27-37-45(35-25-15-11-7-3)47(51)53-43-33-23-21-29-39-49(41-31-32-42-50)40-30-22-24-34-44-54-48(52)46(36-26-16-12-8-4)38-28-20-18-14-10-6-2/h45-46,50H,5-44H2,1-4H3

InChI key

QGWBEETXHOVFQS-UHFFFAOYSA-N

SMILES string

O=C(C(CCCCCC)CCCCCCCC)OCCCCCCN(CCCCO)CCCCCCOC(C(CCCCCCCC)CCCCCC)=O

assay

>99% (TLC)

form

oil

packaging

pkg of 1x1 g (890900O-1G), pkg of 1x100 mg (890900O-100MG), pkg of 1x200 mg (890900O-200MG), pkg of 1x25 mg (890900O-25MG), pkg of 1x50 mg (890900O-50MG), pkg of 1x500 mg (890900O-500MG)

manufacturer/tradename

Avanti Research™ - A Croda Brand

technique(s)

thin layer chromatography (TLC): suitable

application(s)

advanced drug delivery

lipid type

cationic lipids

shipped in

dry ice

storage temp.

−20°C

Application


  • Cationic Lipid Pairs Enhance Liver-to-Lung Tropism of Lipid Nanoparticles for In Vivo mRNA Delivery.: ALC-0315 plays a critical role in this study, enhancing the delivery efficiency of mRNA therapies from liver to lung. This research could lead to improved treatment options for various pulmonary diseases (Zeng et al., 2024).

  • Engineering LNPs with polysarcosine lipids for mRNA delivery.: Demonstrates ALC-0315′s application in designing lipid nanoparticles that efficiently deliver mRNA, showcasing potential advancements in gene therapy (Kang et al., 2024).

  • Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy.: Utilizes ALC-0315 in the development of lipid nanoparticles that activate under tumor-specific conditions to deliver immunotherapeutic agents, offering a targeted approach to cancer treatment (Jiang et al., 2024).

Packaging

  • 5 mL Amber Glass Screw Cap Vial (890900O-25MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-50MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-100MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-200MG)
  • 5 mL Amber Glass Screw Cap Vial (890900O-500MG)
  • 30 mL Amber Glass Screw Cap Vial(890900O-1G)

Other Notes

Quantities limited to 50G in a calendar year per customer.

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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