产品名称
PGA1, Prostaglandin A1, powder
SMILES string
O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1
InChI
1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18?/m0/s1
InChI key
BGKHCLZFGPIKKU-BGEXMHJYSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (900115P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 900115P
shipped in
dry ice
storage temp.
−20°C
General description
Prostaglandin A1(PGA1) belongs to the class of cyclopentenone prostaglandin. PGA1 is generated by the dehydration of prostaglandin E1 (PGE1).
Prostaglandins (PG) are hormones present in many tissues and organs. They are long chain polyunsaturated fatty acids. PGA1 is a cyclopentenone molecule.
Application
Prostaglandin A1(PGA1) has been used to activate Ca2+ channel of human sperm (CatSper).
Biochem/physiol Actions
Prostaglandin A1 (PGA1) boosts the expression of human liver-specific cytochrome P450 4F3B (CYP4F3B) and stimulates the synthesis of 20-hydroxy-eicosatetraenoic acids (HETEs). It has an ability to stimulate cell differentiation, ferritin synthesis and heat shock response in human cells. PGA1 exhibits antitumor and antiviral activities. In addition, it also elicits anti-inflammatory effects by activating peroxisome proliferator-activated receptor (PPAR). Elevated levels of PGA1 has been observed in hypertension patients.
Prostaglandins (PG) mediates various physiological functions and the action of blood vessels. PGA1 also inhibits viral replication and promotes heat shock protein (HSP) expression, exhibiting neuroprotection. PGA1 is known to relieve cellular stress.
Packaging
5 mL Amber Glass Screw Cap Vial (900115P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Regulation of prostaglandin A1-induced heat shock protein expression in isolated cardiomyocytes
Cornelussen RNM, et al.
Journal of Molecular and Cellular Cardiology, 33(8), 1447-1454 (2001)
n-3 Omega fatty acids: a review of current knowledge
Gogus U and Smith U
International Journal of Food Science and Technology, 45(3), 417-436 (2010)
Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells
Wang X, et al.
Journal of Neurochemistry, 83(5), 1094-1102 (2002)
Induction of ferritin and heat shock proteins by prostaglandin A1 in human monocytes: Evidence for transcriptional and post-transcriptional regulation
Elia G, et al.
European Journal of Biochemistry, 264(3), 736-745 (1999)
Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine
Gobbetti T, et al.
PLoS ONE, 8(9), e75581-e75581 (2013)
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