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经验公式（希尔记法）:
C22H32O3
化学文摘社编号:
分子量:
344.49
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
17(S)-HDHA, Avanti Research™ - A Croda Brand 900125E, ethanol solution
InChI
1S/C22H32O3/c1-2-3-15-18-21(23)19-16-13-11-9-7-5-4-6-8-10-12-14-17-20-22(24)25/h3,5-8,11-16,19,21,23H,2,4,9-10,17-18,20H2,1H3,(H,24,25)/b7-5-,8-6-,13-11-,14-12-,15-3-,19-16+/t21-/m0/s1
InChI key
SWTYBBUBEPPYCX-YTQNUIGOSA-N
SMILES string
CC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O
assay
>99% (TLC)
form
ethanol solution
packaging
pkg of 1 × 1 mL (900125E-100ug)
pkg of 1 × 1 mL (900125E-500ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 900125E
concentration
0.1 mg/mL (900125E-100ug)
0.5 mg/mL (900125E-500ug)
lipid type
neutral lipids
neutral glycerides
shipped in
dry ice
storage temp.
−70°C
Biochem/physiol Actions
Docosahexaenoic acid (DHA) exhibits various physiological processes such as regulating signal transduction pathways, neurotransmission, production of neurons and formation of myelin sheath around the axon. It is also associated with the membrane receptor function and synaptic plasticity. DHA supports membrane integrity, fluidity and organization. It is also found to be involved in neuroinflammation. DHA plays a vital role in the development and maturation of the brain. 17(S)-HDHA (hydroxy docosahexaenoic acid) can serve as a precursor for specialized pro-resolving mediators (D-series).
General description
Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (PUFA) with 22 carbons and six double bonds. The first double bond occurring at position three from the methyl terminus (22:6 n-3). DHA is a component of phospholipid membranes and the myelin sheath. It is the most abundant PUFA found in the brain and localized predominantly to the gray matter.
Packaging
2 mL Amber Glass Sealed Ampule (900125E-100ug)
2 mL Amber Glass Sealed Ampule (900125E-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
55.4 °F - closed cup
flash_point_c
13.0 °C - closed cup
法规信息
危险化学品
此项目有
Michael J Weiser et al.
Nutrients, 8(2), 99-99 (2016-02-24)
Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid (PUFA) found in the brain and can affect neurological function by modulating signal transduction pathways, neurotransmission, neurogenesis, myelination, membrane receptor function, synaptic plasticity, neuroinflammation, membrane integrity and membrane organization.
Principles of Nutrigenetics and Nutrigenomics: Fundamentals of Individualized Nutrition, 460-460 (2019)
Miaomiao Ruan et al.
Journal of the neurological sciences, 396, 247-253 (2018-12-12)
Glioblastoma (GBM) is a typical malignant tumor, and there are no effective drugs capable of improving patient survival. Docosahexaenoic acid (DHA), a nutrient essential to animal health and neurodevelopment, exerts an anticancer effect in several types of cancer. However, the
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