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关于此项目
经验公式（希尔记法）:
C20H32O3
化学文摘社编号:
分子量:
320.47
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
15(S)-HETE, Avanti Research™ - A Croda Brand, ethanol solution
assay
>99% (TLC)
InChI key
JSFATNQSLKRBCI-VAEKSGALSA-N
SMILES string
O[C@@H](CCCCC)\C=C\C=C/C\C=C/C\C=C/CCCC(=O)O
InChI
1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1
form
ethanol solution
packaging
pkg of 1 × 1 mL (900128E-100UG)
pkg of 1 × 1 mL (900128E-500UG)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
100 μg/mL in ethanol (900128E-100UG)
500 μg/mL in ethanol (900128E-500UG)
shipped in
dry ice
storage temp.
−70°C
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Biochem/physiol Actions
15(S)-HETE plays a role in various biological actions. It may play a role in pathogenesis and prevention of airway inflammatory disorders. 15(S)-HETE is involved in inhibiting cell proliferation and induces apoptosis in various human cancers.
General description
15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).
Packaging
2 mL Amber Glass Sealed Ampule (900128E-100UG and 900128E-500UG)
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
55.4 °F
flash_point_c
13 °C
法规信息
危险化学品
此项目有
15 (S)-HETE modulates LTB4 production and neutrophil chemotaxis in chronic bronchitis
Profita M, et al.
American Journal of Physiology. Cell Physiology, 279(4), C1249-C1258 (2000)
Huiling Yuan et al.
Thorax, 65(4), 321-326 (2010-04-15)
15-S-Hydroxyeicosatetraenoic acid (15(S)-HETE) and 13-S-hydroxyoctadecadienoic acid (13(S)-HODE), both of which are metabolites of 15-lipoxygenases (15-LOXs), are endogenous ligands for peroxisome proliferator-activated receptor gamma (PPARgamma). The activation of PPARgamma inhibits cell growth and induces apoptosis in some cancers. The role of
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