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Merck
CN

900130E

Avanti

13(S)HODE

Avanti Research™ - A Croda Brand

别名:

13S-Hydroxy-9Z,11E-octadecanoic acid

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关于此项目

经验公式（希尔记法）:
C18H32O3
化学文摘社编号:
29623-28-7
分子量:
296.44
MDL number:
MFCD00065833
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

13(S)HODE, Avanti Research™ - A Croda Brand (900130E), ethanol solution

SMILES string

O[C@@H](CCCCC)\C=C\C=C/CCCCCCCC(=O)O

InChI

1S/C18H32O3/c1-2-3-11-14-17(19)15-12-9-7-5-4-6-8-10-13-16-18(20)21/h7,9,12,15,17,19H,2-6,8,10-11,13-14,16H2,1H3,(H,20,21)/b9-7-,15-12+/t17-/m0/s1

InChI key

HNICUWMFWZBIFP-IRQZEAMPSA-N

assay

99% (TLC)

form

ethanol solution

packaging

pkg of 1 × 1 mg (900130E-1mg)
pkg of 1 × 500 μg (900130E-500ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand (900130E)

concentration

1 mg/mL (900130E-1MG)
500 μg/mL (900130E-500UG)

lipid type

neutral glycerides
neutral lipids

shipped in

dry ice

storage temp.

−70°C

Biochem/physiol Actions

13-S-hydroxyoctadecadienoic acid (13(S)HODE) inhibits cell proliferation and induces apoptosis in many human cancers. It also enhances the activity of nuclear factor κ light chain enhancer of activated B cells (NF-κB) in keratinocytes.

General description

13-S-hydroxyoctadecadienoic acid (13(S)HODE) is a metabolite of 15-lipoxygenase (15-LOX). It is an endogenous ligand of peroxisome proliferator-activated receptorγ (PPARγ).

Packaging

2ml Amber Glass Sealed Ampule

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

hcodes

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

存储类别

3 - Flammable liquids

wgk

WGK 1

flash_point_f

55.4 °F

flash_point_c

13 °C

法规信息

危险化学品
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分析证书(COA)

Lot/Batch Number

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Huiling Yuan et al.
Thorax, 65(4), 321-326 (2010-04-15)
15-S-Hydroxyeicosatetraenoic acid (15(S)-HETE) and 13-S-hydroxyoctadecadienoic acid (13(S)-HODE), both of which are metabolites of 15-lipoxygenases (15-LOXs), are endogenous ligands for peroxisome proliferator-activated receptor gamma (PPARgamma). The activation of PPARgamma inhibits cell growth and induces apoptosis in some cancers. The role of
Eisaku Ogawa et al.
The Journal of investigative dermatology, 131(3), 604-612 (2010-11-12)
Fatty acid-binding proteins (FABPs) are postulated to serve as lipid shuttles that solubilize hydrophobic fatty acids and deliver them to appropriate intracellular sites. Epidermal FABP (E-FABP/FABP5) is predominantly expressed in keratinocytes and is overexpressed in the actively proliferating tissue characteristic

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