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Merck
CN

999993C

Avanti

14:0 Diether PC

Avanti Research - A Croda Brand

别名:

1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine

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关于此项目

经验公式(希尔记法):
C36H76NO6P
化学文摘社编号:
分子量:
649.97
UNSPSC代码:
12352211
NACRES:
NA.25
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产品名称

14:0 Diether PC, Avanti Research - A Croda Brand 999993C

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 1 mL (999993C-10mg)
pkg of 1 × 2.5 mL (999993C-25mg)

制造商/商品名称

Avanti Research - A Croda Brand 999993C

浓度

10 mg/mL (999993C-10mg)
10 mg/mL (999993C-25mg)

脂质类型

cardiolipins
phospholipids

运输

dry ice

储存温度

−20°C

SMILES字符串

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OCCCCCCCCCCCCCC)COCCCCCCCCCCCCCC)=O

一般描述

14:0 Diether PC (phosphocholine) is a glycerophospholipid having two tetradecyl chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds. It has choline as the alcohol moiety, attached to the phosphate group.

应用

14:0 Diether PC or 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine might be used:
  • in lipid bicelles to reconstitute EmrE (secondary active transport protein) to study the chain length dependence by differential scanning calorimetry and solid-state nuclear magnetic resonance (NMR)
  • to compose isotropically tumbling small bicelles, to study its size and morphology
  • to prepare bicelle samples for solid-state NMR experiments to determine if the proteins could be reconstituted into phospholipid bilayers

包装

5 mL Clear Glass Sealed Ampule (999993C-10mg)
5 mL Clear Glass Sealed Ampule (999993C-25mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Expression and purification of the membrane protein p7 from hepatitis C virus
Cook GA, et al.
Pept. Sci., 96(1), 32-40 (2011)
Assessing interactions between a polytopic membrane protein and lipid bilayers using differential scanning calorimetry and solid-state NMR
Banigan JR, et al.
The Journal of Physical Chemistry B, 122(8), 2314-2322 (2018)
Assessing the size, stability, and utility of isotropically tumbling bicelle systems for structural biology
Wu H, et al.
Biochimica et Biophysica Acta - Biomembranes, 1798(3), 482-488 (2010)
H A Pérez et al.
Langmuir : the ACS journal of surfaces and colloids, 36(10), 2644-2653 (2020-02-20)
The lack of carbonyl groups and the presence of ether bonds give the lipid interphase a different water organization around the phosphate groups that affects the compressibility and electrical properties of lipid membranes. Generalized polarization of 1,2-di-O-tetradecyl-sn-glycero-3-phosphocholine (14:0 diether PC)
Structural and functional roles of ether lipids
Dean JM and Lodhi IJ
Protein & cell, 9(2), 196-206 (2018)

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